温州地区胰腺癌发病危险因素分析  

Risk factors for pancreatic cancer in Wenzhou area

作　　者：石玲燕[1] 张培趁[2] 黄智铭[1] 林春景[1] 董乐妹[1] 吴建胜[1] 

机构地区：[1]温州医科大学附属第一医院消化内科,浙江温州325000 [2]温州医科大学附属第一医院普外科,浙江温州325000

出　　处：《中华胰腺病杂志》2015年第3期173-176,共4页Chinese Journal of Pancreatology

基　　金：温州市科技局资助（Y20140289）

摘　　要：目的 探讨温州地区胰腺癌发病的危险因素.方法 以病例对照研究方法对经确诊的220例胰腺癌患者及220例匹配的对照人群进行危险因素的条件Logistic回归分析.结果 单因素Logistic分析显示,体重指数（BMI） ＞30 kg/m^2、吸烟、生育胎数、糖尿病、胆囊炎、胆石症、慢性胰腺炎、阑尾切除史、胃手术史、恶性肿瘤史、恶性肿瘤家族史、高脂血症等因素为胰腺癌发病的危险因素.多因素Logistic回归分析显示,吸烟（OR=3.624,95％CI1.474 -8.907）、BMI＞ 30 kg/m^2（OR =1.789,95％ CI1.030 -3.108）、糖尿病（OR =3.191,95％CI1.094-9.309）、慢性胰腺炎（OR=4.972,95％CI1.593-14.898）、胆囊炎（OR =2,289,95％ CI1.024-5.116）是胰腺癌发病的危险因素.结论 BMI＞ 30 kg/m^2、吸烟、糖尿病等是温州地区胰腺癌发病的危险因素。Objective To investigate the risk factors of pancreatic cancer in Wenzhou area.Methods A case control study was conducted on 220 cases with pancreatic cancer and 220 matched controls using conditional logistic regression analysis.Results Univariate analysis showed BMI 〉 30 kg/m^2,smoking,reproductive history,diabetes,cholecystitis,chronic pancreatitis,history of appendectomy,history of partial gastrectomy,history of cancer and familial history of cancer were associated with pancreatic cancer,while multivariate conditional logistic regression analysis showed that the risk factors of pancreatic cancer included smoking （OR =3.624,95% CI i.474 ～ 8.907）,BMI 〉 30 kg/m^2 （OR =1.789,95% CI 1.030 ～ 3.108）,diabetes （OR =3.191,95% CI 1.094 ～ 9.309）,chronic pancreatitis （OR =4.972,95% CI 1.593 ～ 14.898）,and cholecystitis （OR =2.289,95 % CI 1.024 ～5.116）.Conclusions BMI 〉 30 kg/m2,smoking and diabetes are risk factors for pancreatic cancer in Wenzhou area.

关 键 词：胰腺肿瘤 回归分析 危险因素 LOGISTIC模型 

分 类 号：R735.9[医药卫生—肿瘤]