过氧化物酶体增殖物激活受体β在中枢神经系统疾病中的作用  

Effects of PPARβ in central nervous system diseases

作　　者：滕志朋[1] 孙晓川[1] 杨晓波[1] 郭宗铎[1] 

机构地区：[1]重庆医科大学附属第一医院神经外科,重庆400016

出　　处：《重庆医科大学学报》2015年第5期641-644,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金青年基金资助项目(编号:81100865/H0906);国家临床重点专科建设经费资助项目(编号:财社[2011]170号)

摘　　要：过氧化物酶体增殖物激活受体(peroxisome proliferator activated receptors,PPARs)是一类核受体超家族,其成员有PPARα、PPARβ(也称为PPARδ)和PPARγ3种亚型。PPARs自被发现以来受到广泛关注并在各个领域展开研究,其中主要集中在PPARα和PPARγ的研究上,对其在体内的病理生理作用都有了比较深刻的了解,其部分配体也已广泛用于临床治疗,而对PPARβ的研究相对较少。近来有学者认为PPARβ是PPARα和PPARγ激活的连接枢纽,使得其地位更加重要,PPARβ在中枢神经系统疾病中的作用及其调控机制越来越引起人们的关注。但关于PPARβ在中枢神经系统疾病中的作用及机制的研究却远落后于其他2种亚型。本文就PPARβ在中枢神经系统疾病中的作用进行综述。Peroxisome proliferator activated receptors（PPARs）are a class of nuclear receptor superfamily,which is consisted of PPARα,PPARβ（also named PPARδ）and PPARγ. PPARs has been widely concerned and studied in every field since its discovery. The most studies focused on PPARα and PPARγ. Their physiopathological effects in vivo have been profoundly understood,and some of their ligands have been widely used in clinical treatment. However,there were fewer studies about PPARβ. Recently,it is believed that PPARβ is a connection hub of PPARα and PPARγ,making PPARβ more important. An increasing concern was paid on the role and regulation mechanism of PPARβ in central nervous system diseases,however,the researcheson PPARβ were far behind those on PPARα and PPARγ. This article reviews the role of PPARβ in central nervous system diseases.

关 键 词：过氧化物酶体增殖物激活受体β 配体 中枢神经系统疾病 

分 类 号：R365[医药卫生—病理学]