高压氧对缺血性脑卒中患者血液一氧化氮含量影响相关研究的Meta分析  

Effects of hyperbaric oxygen on the changes of nitric oxide in patients with ischemic stroke both before and after therapy：a meta analysis of the 5 research papers

作　　者：谭杰文[1] 邓宝雯[1] 刘河军[1] 龙颖 

机构地区：[1]中山大学附属孙逸仙纪念医院,广州510120 [2]深圳市人民医院

出　　处：《中华航海医学与高气压医学杂志》2015年第2期85-91,共7页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的 通过对高压氧治疗缺血性脑卒中患者一氧化氮（NO）含量变化相关文献的Meta分析,探讨高压氧对缺血性脑卒中的治疗作用.方法 通过PUBMED、中国期刊网全文数据库（CNKI）、EMBASE等数据库及论文集检索国内外至2014年8月1日的相关文献.选择对缺血性脑卒中患者接受高压氧治疗患者与常规治疗患者治疗前后的对照研究,并对2组NO含量的变化进行Meta分析.结果 5篇文献符合纳入标准,涉及研究对象352例.高压氧治疗前后与常规治疗组前后NO含量经Meta分析的结果为OR =4.921（95％可信区间1.983 ～ 12.213）,显示缺血性脑卒中患者经高压氧治疗后NO含量明显上升且为常规治疗组的4.921倍.结论 高压氧治疗缺血性脑卒中有较好的应用前景,值得进一步临床研究.Objective Researches have demonstrated that hyperbaric oxygen therapy （HBOT） could quickly elevate levels of nitric oxide （NO） in patients with ischemic stroke.By meta-analysis,this paper attempts to explore the efficacy of HBOT in patients with ischemic stroke.Methods Related literature was retrieved through the access of PUBMED,CNKI,EMBASE databanks from the inception to 2014-08-01,and controlled studies of patients treated with HBO and those treated with routine therapy were chosen from the retrieved literature,and then results of the meta-analysis were used to evaluate changes in the NO levels of ischemic stroke patients treated with HBO （the HBO group） and routine treatment （the sham group）.Results There were 5 papers that were conformed to our selection criteria,with a total of 352 cases included.The meta-analysis showed that the odd ratio （OR） of NO levels for the patients in the HBO group and those of the sham group were respectively [4.921 （95％ CI was 1.983-12.213）].It was indicated that the NO level of the patients in the HBO group could obviously be elevated following HBO therapy,and was 4.921 times higher than that of the routine therapy group.Conclusions Present evidences indicated that HBO promised to have good clinical application in the treatment of patients with ischemic stroke,and was worth further clinical trial.

关 键 词：缺血性脑卒中 一氧化氮 高压氧 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]