SonoVue剂量与健康实验兔肾超声造影效果关系的实验研究  

Dose-response Relationship of Sono Vue and Contrast-enhanced Ultrasound: An Experimental Study in Healthy Rabbits

作　　者：刘锐洪[1] 李叶阔[2] 孙彬录[2] 何晶玲 袁桂忠[2] 王莎莎[2] 

机构地区：[1]广东医学院附属陈星海医院超声科,广东中山528415 [2]广州军区广州总医院超声科,广东广州510010

出　　处：《中国医学影像学杂志》2015年第6期401-404,共4页Chinese Journal of Medical Imaging

基　　金：全军医学科研"十二五"计划课题项目(CWS12J076);广东省科技计划项目(2011B080701019;2012B031800309)

摘　　要：目的 探讨不同Sono Vue剂量对健康实验兔超声造影（CEUS）效果的影响,并分析其变化规律,探讨最佳Sono Vue剂量。材料与方法 采用GE LOGIQ-E9超声诊断仪,分别对10例兔肾在8个Sono Vue剂量水平（0.02~0.16 ml/kg）行CEUS检查,通过时间-强度曲线测量肾血流灌注参数,并进行定量分析。结果 Sono Vue在0.02~0.10 ml/kg剂量范围内,峰值强度（PI）及曲线下面积（AUC）随剂量增加而增大,Sono Vue剂量与PI、AUC呈显著正相关（r=0.962、0.965,P〈0.05）;进一步增加剂量,AUC变化不明显,PI反呈略下降趋势。到达时间（AT）随Sono Vue剂量的增加而呈逐渐缩短,两者呈显著负相关（r=-0.917,P〈0.05）;Sono Vue剂量与达峰时间（TTP）呈正相关（r=0.49,P〈0.05）。结论 Sono Vue剂量会影响CEUS定量分析结果,确定剂量和效果的关系及认识其规律是进行CEUS和定量分析的前提条件。应用Sono Vue对健康实验兔肾行CEUS定量分析时,0.10 ml/kg是较理想的剂量。Purpose To study the effects of different doses of ultrasound contrast agent SonoVue upon contrast-enhanced ultrasound （CEUS） in the kidney of healthy rabbits, and to seek the optimal dose of SonoVue. Materials and Methods CEUS was performed in 10 healthy rabbits with GE LOGIQ-E9 by using 8 different doses of SonoVue （ranging from 0.02 ml/kg to 0.16 ml/kg）. The quantitative parameters of the time-intensity curve （TIC） were measured and statistically compared. Results The TICs showed that the peak intensity （PI） and the area under curve （AUC） increased with dose when the doses ranged from 0.02 ml/kg to 0.10 ml/kg （r=0.962 and 0.965, P〈0.05）; when the dose further increased, AUC had little change but PI decreased reversely. The arrival time （AT） shortened along with the increase of the SonoVue dose （r= -- 0.917, P〈0.05）. The dose had a positive correlation with time to peak （r=0.49, P〈0.05）. Conclusion The parameters of TIC are influenced intensely by different doses of SonoVue. It is important to realize the relationship between SonoVue doses and its effects upon contrast-enhancement ultrasound in microcirculatory quantification. The dose of 0.10 ml/kg appears to be the optimal dose for CEUS in examining kidney of healthy rabbit.

关 键 词：造影剂 超声检查 超声造影 剂量效应关系 药物 肾循环 模型 动物 兔 

分 类 号：R-33[医药卫生] R445.1