含左氧氟沙星的三联疗法治疗幽门螺杆菌阳性十二指肠溃疡的疗效分析  

Efficacy of triple therapy with levofloxacin in the treatment of Helicobacter pylori-positive duodenal ulcer

作　　者：崔姗姗[1] 张豹[1] 张诒凤 付明燕[2] 张汝建[2] 

机构地区：[1]泰山医学院,山东泰安271016 [2]泰山医学院附属医院,山东泰安271000

出　　处：《泰山医学院学报》2015年第3期266-267,共2页Journal of Taishan Medical College

摘　　要：目的探讨含左氧氟沙星的三联疗法治疗幽门螺杆菌阳性十二指肠溃疡的疗效及安全性。方法选择我院收治的十二指肠溃疡患者70例。随机分为研究组与对照组,研究组采用左氧氟沙星200 mg,2次/d;阿莫西林1.0 g,2次/d;泮托拉唑40 mg,1次/d。对照组给予传统的克拉霉素500 mg,2次/d代替左氧氟沙星。结果疗程结束4周后复查电子胃镜和Hp根除率,研究组94.3%,对照组77.1%,差异比较有统计学意义(P<0.05)。副反应发生率对照组17.1%,研究组11.4%,对照组高于研究组,但差异比较无统计学意义(P>0.05)。结论含左氧氟沙星的三联疗法根除幽门螺杆菌阳性的十二指肠溃疡的疗效好,但应严密观察副反应。Objective：To investigate the triple therapy with levofloxacin treatment of Helicobacter pylori-positive duode-nal ulcer efficacy and safety. Methods：Seventy cases of patients with duodenal ulcer were randomly divided into the study group and the control group in our hospital. The study group received levofloxacin 200mg,2 times/d;amoxicillin：1. 0 g, 2 times/ d;pantoprazole 40mg,1 times/d while the control group received conventional clarithromycin 500mg,2 times/d instead of levofloxacin. Results：Four weeks after the end of treatment,electronic endoscopy was made,and Hp eradication rate was 94. 3% in the study group and 77. 1% in the control group,and the difference was statistically significant（ P〉0. 05）. Incidence of side effects in the control group was 17. 1%,and 11. 4% in the study group,which was higher in the control group than in the study group,but the difference was not statistically significant（ P〉0. 05 ）. Conclusion：Triple therapy with levofloxacin is effective eradication of H. pylori-positive duodenal ulcer,but side effects should be closely ob-served.

关 键 词：三联疗法 幽门螺杆菌 克拉霉素 左氧氟沙星 

分 类 号：R573.1[医药卫生—消化系统]