肿瘤相关转移因子-1、p53蛋白与子宫内膜癌临床病理的相关性  

Correlation of metastasis-associated gene 1 and p53 with clinicopathologic features of endometrial cancer

作　　者：李俊军[1,2] 何艳 唐洁[1,2] 欧阳强 

机构地区：[1]湖南省肿瘤医院 [2]中南大学湘雅医学院附属肿瘤医院病理科,湖南长沙410013

出　　处：《海南医学》2015年第13期1997-2000,共4页Hainan Medical Journal

摘　　要：目的探讨肿瘤相关转移因子-1(MTA-1)及p53蛋白对子宫内膜癌临床诊断和预后评估的应用价值。方法对31例子宫内膜癌、19例不典型增生及26例正常子宫内膜组织的病理切片进行免疫组化研究,观察MTA-1和p53蛋白的表达差异,并分析子宫内膜癌组织MTA-1和p53蛋白表达与临床病理特征的关系。结果子宫内膜癌、不典型增生及正常子宫组织的MTA-1阳性表达率分别为11.5%、47.4%、83.9%,p53蛋白阳性表达率分别为7.69%、36.8%、67.7%,其组间差异均有统计学意义(P<0.05);其表达量的变化与表达率一致,且组间差异均有显著统计学意义(P<0.01)。MTA-1和p53蛋白表达量受到子宫内膜癌TNM分期、组织学分级、浸润深度、淋巴结转移和ER阳性的影响(P<0.05),且两者之间具有显著正相关性(r2=0.6248,P<0.01)。结论 MTA-1及p53蛋白与子宫内膜癌发生、发展及病理进程密切相关,可为其临床诊断和预后评估提供指导。Objective To explore the application value of metastasis-associated gene 1（MTA-1） and p53 in the clinical diagnosis and prognosis assessment of endometrial cancer. Methods Pathological sections from 31 cases of endometrial cancer, 19 cases of atypical hyperplasia and 26 cases of normal endometrial tissues were selected, and MTA-1 and p53 protein expression were detected by immunohistochemical assay. The relations of MTA-1 and p53 protein expression with clinicopathologic features of patients were analyzed. Results The MTA-1 positive rate of endometrial cancer, atypical hyperplasia and normal endometrial tissues were 11.5%, 47.4% and 83.9%, and the p53 positive rate were 7.69%, 36.8% and 67.7%, respectively, with statistically significant differences between the two groups（P0.05）. The change of expression quantity was in accordance with that of positive rate, with statistically significant difference between the two groups（P0.01）. The MTA-1 and p53 expression were influenced by TNM stage, histological grade, infiltration depth, lymph node metastasis and the ER positive（P0.05）, with positive correlations（r2=0.6248, P0.01）. Conclusion MTA-1 and p53 are closely related to the occurrence, development and pathological process of endometrial cancer, which can provide guidance for its clinical diagnosis and prognosis assessment.

关 键 词：肿瘤相关转移因子-1 P53蛋白 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]