南京地区缺血性脑卒中二级预防中危险因素的调查分析  

Investigation of risk factors of ischemic stroke in secondary prevention in Nanjing area

作　　者：许海燕[1] 王小姗[1] 刘卫国[1] 林兴建[1] 冯智 张霞 蔡兴秋[1] 逯恒东[4] 刘犇[4] 尹俊雄[1] 于翠玉[1] 许媛媛[1] 张书刚[1] 魏砚秋[5] 凌晓辉[1] 刘晓卫[1] 

机构地区：[1]南京脑科医院神经内科,210029 [2]江宁区疾控中心 [3]建邺区疾控中心 [4]南京脑科医院物理诊断科,210029 [5]南京脑科医院急诊科,210029

出　　处：《临床神经病学杂志》2015年第3期181-184,共4页Journal of Clinical Neurology

基　　金：南京市卫生局医学科技发展重大项目(ZDX12007)

摘　　要：目的：调查并分析南京地区缺血性脑卒中二级预防中的危险因素。方法现将2013年03月～2013年12月在南京脑科医院门诊就诊的有过脑梗死（ CI ）病史或期间有CI发病的患者886例（ CI组）和头颅MRI显示仅有腔隙性脑梗死（ LI）病灶但无卒中发作史的患者1247例（ LI组）进行资料采集，包括性别、年龄、吸烟史、高血压、糖尿病、房颤史、心肌梗死史、外周动脉疾病、颅内外动脉狭窄情况及Essen卒中风险评分量表（ ESRS）。同时收集南京汤山社区和南湖社区缺血性脑卒中中低危人群9739例（ LR组）的相关数据，对三组数据进行分析比较。结果 CI组和LI组高血压、糖尿病比率显著高于LR组（均P＜0．01）。 CI组颅内外动脉狭窄比率显著高于LI组（ P＜0．01）。进一步将脑梗死的六个危险因素进行多元Logistic回归分析结果均无统计学意义。 CI组与LI组ESRS风险分级比例之间比较无统计学差异。结论南京地区高血压、糖尿病是CI的常见危险因素。在缺血性脑卒中的危险因素中对颅内外动脉狭窄的监测更为重要。Objective To investigate the risk factors of ischemic stroke in secondary prevention in Nanjing area.Methods The data of 886 patients in clinics of Nanjing Brain Hospital from March 2013 to December 2013 who had history of cerebral infarction （ CI ） or had CI outbreak （ CI group ） and 1247 patients who had only lacunar infarction （LI） lesions but no stroke history（LI group） were registered, including sex, age, smoking, hypertension, diabetes, atrial fibrillation,myocardial infarction, peripheral arterial disease, intracranial and extracranial artery stenosis,Essen score.Also, the related data of low risk population in 9739 cases （ LR group） of Nanjing Tangshan and Nanhu community were collected , and risk factors of the three groups were compared .Results The risk rates of diabetes and hypertension in CI group and LI group were significantly higher than those in LR group （all P〈0.01）. The rate of intracranial and extracranial artery stenosis in CI group was significantly higher than that in LI group （ P〈0.01）.There were no significant differences in muti-logistic regression of six risk factors of cerebral infarction .And there were no significant differences in ESRS between CI group and LI group .Conclusions Hypertension and diabetes are the common risk factors of CI in Nanjing area .The monitoring of intracranial and extracranial artery stenosis was more important in these risk factors for ischemic stroke .

关 键 词：缺血性脑卒中 二级预防 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]