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作 者:李永金[1] 杨开勇[1] 张谊[1] 陈月芳[1] 黄晓佳[1]
机构地区:[1]江苏大学医学院,镇江212013
出 处:《中国细胞生物学学报》2015年第6期906-910,共5页Chinese Journal of Cell Biology
基 金:国家自然科学基金(批准号:81300059);江苏大学高级人才基金(批准号:08JDG005;11JDG092)资助的课题~~
摘 要:低氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)作为目前发现的具有高度特异性感受细胞氧分压的调节因子,在脑损伤发生、发展过程中发挥着重要的双向调节作用。HIF-1在轻度和中度脑损伤过程中可以增加神经细胞耐受,促进存活;在重度损伤时,参与细胞凋亡途径,促进神经细胞死亡,在脑损伤中发挥重要作用。对HIF-1及其信号通路的深入研究可为脑损伤的治疗提供药物作用靶点,有重要的理论研究和实用价值。现就HIF-1的结构、功能及在脑损伤中的调节作用进行综述,为临床治疗脑损伤提供参考。Hypoxia-inducible factor-1(HIF-1) was found as a regulator factor of high specificity, which was able to perceive oxygen partial pressure of cells and played an important two-way adjustment role in brain injury and its developing process. HIF-1 could increase nerve cell tolerance and facilitate survival in the process of mild and moderate brain injury; when severe injury occured, it could involve in cell apoptosis and facilitate neuronal cell's death, so it played an important role in brain injury. In-depth study of the HIF-1 and its signaling pathway can provide drug targets in treatment of brain injury and have important theoretical and practical value. Now reviewing on HIF-1 structure, function and regulation of the brain injury is to provide reference for clinical treatment of brain injury.
分 类 号:R741[医药卫生—神经病学与精神病学]
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