^(18)F-FDGPET-CT对肺部占位性病变的诊断价值  

The Diagnostic Value of ^(18)F-FDG PET-CT for Lung Occupying Lesion

作　　者：张静[1] 任树华[2] 张媛媛[1] 何剑[1] 陈小东[1] 朱柠[1] 

机构地区：[1]复旦大学附属华山医院呼吸科 [2]复旦大学附属华山医院PET中心

出　　处：《中国医学计算机成像杂志》2015年第3期294-297,共4页Chinese Computed Medical Imaging

摘　　要：目的:探讨18氟-氟代脱氧葡萄糖(18F-FDG)正电子发射计算机断层扫描(PET-CT)最大标准摄取值(SUVmax)对肺癌的诊断价值及主要影响因素。方法:本研究收集2012年6月至2013年12月在我院就诊的158例肺部占位性病变患者,进行回顾性研究,分析18F-FDG SUVmax与病理类型、肿瘤大小、肿瘤标志物之间的关系,探讨对肺癌的诊断价值。结果:恶性病变的SUVmax值为10.21±5.77,良性病变的SUVmax值为5.22±3.95,两组之间有显著性差异(P=0.022)。鳞癌(12.18±6.18)>腺癌(9.26±5.7),P=0.032,差异有统计学意义。SUVmax与病灶大小低度相关(r=0.339,P<0.01),与血清CEA水平显著相关(r=0.286,P=0.003)。PETCT SUVmax诊断肺癌的曲线下面积为0.767,有较高的诊断价值。当SUVmax=5.4,灵敏度为78.2%,特异度为60.4%。结论:PET-CT SUVmax对肺癌有较高的诊断价值,且和病理类型、病灶大小明显相关。Purpose： To explore the diagnostic value of fluorodeoxyglucose （18F-FDG） positron emission tomography/computed tomography （PET/CT） for lung cancer and major effect factors of maximum standard uptake value （SUVmax）. Methods： One hundred and fifty-eight patients of pulmonary space-occupying lesions at Huashan Hospital from June 2012 to December 2013 were included in this retrospective analysis. It＇ s aimed to evaluate the relationship between 18F-FDG SUVmax and pathologic types, lesion size and serum tumor markers of lung cancer. And the diagnostic value of PET-CT SUVmax for lung cancer was also evaluated by ROC curve. Results： The mean SUVmax in malignant lesions was 10.215：5.77, which was significantly larger than that of benign lesions（5.22±3.95, P=0.022）. And SUVmax was higher in squamous cell carcinomathan than that in adenocarcinoma （12.18±6.18 vs 9.26＋5.7, P=0.032）. SUVmax was significantly correlated with lesion size （r=0.339, p〈0.01） and serum level of CEA （r=0.286, p=0.003）. The area under curve of ROC was 0.767, which showed quite higher diagnostic value of PET-CT SUVmax. The sensitivity, specificity were 78.2%, 60.4% with a SUVmax cutoff of 5.4 for malignant lesion. Conclu- sion： PET-CT SUVmax has higher diagnostic value for lung cancer, which is significantly correlated with pathologic type and lesion size.

关 键 词：18F-FDG正电子发射计算机断层扫描 肺癌 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]