新疆地区维汉妇女宫颈病变组织中Pokemon与P14ARF表达情况的研究  

Expressions of Pokemon and P14ARF in different lesions cervical tissues between Uygur and Han women

作　　者：刘玉婵[1] 周瑾[2] 付勇[3] 

机构地区：[1]新疆石河子大学医学院,新疆石河子832000 [2]兰州军区乌鲁木齐总医院妇产科,新疆乌鲁木齐830000 [3]兰州军区乌鲁木齐总医院病理科,新疆乌鲁木齐830000

出　　处：《中国优生与遗传杂志》2015年第7期26-27,64,F0003,共4页Chinese Journal of Birth Health & Heredity

基　　金：兰州军区乌鲁木齐总医院博士返院后续课题资助项目(2013ZY003)

摘　　要：目的探讨新疆地区维汉妇女宫颈疾病及其癌变组织中Pokmon蛋白与P14ARF蛋白的表达及意义。方法采用免疫组化SP法检测240例新疆地区维汉族妇女宫颈病变中Pokmon蛋白和P14ARF蛋白的表达。维汉妇女各120例,依据病理诊断结果分为4组,非瘤变组(正常及慢性炎症组)30例、CINⅠ组30例、CINⅡ—Ⅲ组30例、宫颈鳞癌组30例。结果宫颈病变组织中Pokemon与P14ARF蛋白在维汉族之间的表达差异无显著性(P>0.05);随着宫颈病变程度的加重,不同组别之间Pokemon与P14ARF蛋白的表达有显著差异(P<0.05)。结论 Pokemon蛋白与P14ARF蛋白表达与宫颈疾病及其癌变的发生密切相关,呈正相关,Pokemon蛋白与P14ARF蛋白在新疆地区维汉妇女宫颈病变及其癌变中表达不存在民族差异。Objective：To study the expressions and significance of Pokemon protein and P14 ARF protein between Uygur and Han women with cervical disease or cancer in Xinjiang.Methods：240 cases of Uygur and Han women with cervical diseases were collected for detecting the expressions of Pokemon protein and P14 ARF protein in cervical lesions by using immunohistochemistry SP method. According to the pathological diagnosis,120 cases Uygur women and 120 cases Han women were divided into four groups：non-neoplasia group（normal and chronic inflammatory group）,CINⅠ group,CIN Ⅱ-Ⅲ group,cervical squamous cell carcinoma group,each group were 30 cases. Results：There was no significant difference in the expressions of Pokemon protein and P14 ARF protein between Uygur and Han women（P〉0.05）;With the deterioration of cervical lesions degree,the expressions of Pokemon protein and P14 ARF protein had significant difference between different groups（P〈0.05）. Conclusion：There is a close and positive correlation between the expression of Pokemon protein and P14 ARF protein and the incidence of cervical disease and cancer. There is no ethnic differences of the expressions of Pokemon protein and P14 ARF protein between Uygur and Han women with cervical disease or cancer in Xinjiang.

关 键 词：宫颈鳞癌 宫颈病变 Pokemon蛋白 P14ARF蛋白 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]