Sin3A蛋白调节细胞功能综述  

Sin3A regulates cell functions

作　　者：张梓卉 王振东[1] 白光宇[1] 张娜[1] 李彤[1] 雷蕾[1] 

机构地区：[1]哈尔滨医科大学组织学与胚胎学教研室,哈尔滨150081

出　　处：《生命科学》2015年第7期892-897,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31271590)

摘　　要：SIN3转录调控蛋白家族成员A(SIN3 transcription regulator family member A,Sin3A)包含许多蛋白质相互作用结构域,是一个多蛋白的转录共阻遏复合物的核心组分,通过结合该转录阻遏复合物中的组蛋白去乙酰化酶(histone deacetylase,HDAC)起到转录抑制的作用。Sin3A通过与不同的功能蛋白,如Mad(Max dimerization protein)-Max(MYC associated factor X)、Myc(Myelocytomatosis oncogene)、甲基Cp G结合蛋白2(Methyl Cp G binding protein 2,Mecp2)等相互作用,在细胞增殖、分化、凋亡,肿瘤的形成、细胞周期调控、植入前胚胎发育以及组织器官发育过程中扮演重要角色。近来有研究表明,Sin3A在体细胞重编程过程中显著上调,因此,Sin3A可能在体细胞重编程中也起到重要作用。SIN3 transcription regulator family member A （Sin3A） contains a lot of protein interaction domains. It is a core component of transcription repression complex, in which it can repress transcription through combining histone deacetylase （HDAC）. By interacting with other proteins, such as Mad-Max, Myc, Mecp2, Sin3A plays very important roles in cell proliferation, differentiation, apoptosis, formation of tumor, cell cycle regulation, preimplantation embryonic development, tissues and organs development. Recent research reported that Sin3A was upregulated significantly in somatic cell reprogramming, indicating a potential function of Sin3A in this process.

关 键 词：Sin3A/HDAC复合物 细胞功能调控 早期胚胎发育 体细胞重编程 

分 类 号：Q813[生物学—生物工程] R363.21[医药卫生—病理学]