酰胺型冠醚稀土配合物的合成及其与DNA的作用  

Synthesis of Amide-type Crown Ether Rare Earth Complex and Its Interaction with DNA

作　　者：高继红[1] 杨天林[2] 

机构地区：[1]宁夏大学学术期刊中心,宁夏银川750021 [2]宁夏大学能源化工重点实验室,宁夏银川750021

出　　处：《河北师范大学学报（自然科学版）》2015年第4期325-332,共8页Journal of Hebei Normal University：Natural Science

基　　金：国家自然科学基金(21261018)

摘　　要：以2,3-二羟基萘为母体,合成2种酰胺型配体,配体再与稀土苦味酸盐(Pic)合成系列稀土配合物.通过元素分析、摩尔电导率、红外光谱、核磁共振光谱、差热-热重分析对配体及其稀土配合物的组成和可能的结构进行了表征,通过紫外吸收光谱、荧光发射光谱、循环伏安法和黏度测定分析方法考查了2个配体的Eu(Ⅲ)配合物与ct-DNA结合的模式.结果表明,2个系列稀土配合物的组成为[RE(Pic)2L](Pic)(L1=C38H30N2O4,L2=C42H38N2O4,RE=Eu(Ⅲ),Tb(Ⅲ),Ce(Ⅲ),Y(Ⅲ)),2个配体的Eu(Ⅲ)配合物均有较强的荧光发射,与ct-DNA通过插入模式结合,且[RE(Pic)2L2](Pic)与ct-DNA间的作用力大于[RE(Pic)2L1](Pic)的.Two types of rare earth complexes were composited as the derivatives of 2,3-dihydroxy naphthalene. The compositions and constructions of compounds were represented by the approaches of element analysis, molar conductivity, infrared spectroscopy, nuclear magnetic resonance spectroscopy and scanning calorimetry-thermogravimetric analysis. The interaction between the rare earth complex and ct- DNA was also studied by the means of ultraviolet absorption spectrum, fluorescence spectra, cyclic voltammetry,and Viscosity test. The results indicate that,the compositions of this series of complexes are [RE （Pic） 2 L] （Pic） （L1 =C38 H30N2O ,L2 =C42 H38 N2 O4 ,RE= Eu（ Ⅲ） ,Tb（ Ⅲ ） ,Ce（ Ⅲ ） ,Y（ Ⅲ） ） ,and the Eu（Ⅲ） compounds of two ligands are strong in fluorescence-emission. The compounds are combined with ct-DNA by means of insert mode, and the acting force between [-RE（Pie）2 L2 ] （Pie） and ct-DNA is stronger than that between [RE（Pic）2L1]（Pic） and ct-DNA.

关 键 词：2  3-二羟基萘 稀土配合物 DNA 作用 

分 类 号：O614[理学—无机化学]