新辅助放化疗对腹腔镜直肠癌手术病人近期临床结局影响  

EFFECTS OF NEOADJUVANT CHEMORADIOTHERAPY ON SHORT-TERM CLINICAL OUTCOMES IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERY FOR RECTAL CANCER

作　　者：卢琦[1] 赵萍[1] 周岩冰[1] 王东升[1] 

机构地区：[1]青岛大学附属医院普外科,山东青岛266003

出　　处：《齐鲁医学杂志》2015年第4期445-447,共3页Medical Journal of Qilu

摘　　要：目的探讨新辅助放化疗对腹腔镜直肠癌手术病人近期临床结局的影响。方法回顾性分析47例新辅助放化疗后行腹腔镜手术的直肠癌病人(新辅助组)与同期58例仅行腹腔镜手术的直肠癌病人(对照组)的临床资料。比较两组病人的手术相关指标、并发症发生率及病理学指标。结果两组病人术前临床资料比较差异无显著统计学意义(P>0.05)。新辅助组回肠末端造口率高于对照组;淋巴结清扫数目明显低于对照组,差异均有显著统计学意义(χ2=25.694,t=4.818,P<0.05)。其余手术相关指标、并发症发生率两组间差异均无统计学意义(P>0.05)。结论新辅助放化疗后行腹腔镜直肠癌手术是安全、可行的,并不增加术后并发症。Objective To investigate the effects of neoadjuvant chemoradiotherapy on short-term clinical outcomes in patients received laparoscopic surgery for rectal cancer. Methods A retrospective analysis of clinical data was done in 47 patients with rectal cancer underwent laparoscopic surgery following neoadjuvant chemoradiotherapy（neoadjuvant therapy group）,and 58 patients with the same condition received laparoscopic surgery alone（control group）during the same period.The surgical parameters,postoperative complications and pathological indicators between the two groups were compared. Results The preoperative conditions between the two groups were not significantly different（P〉0.05）.The rates of terminal-ileum fistulation in the neoadjuvant therapy group were higher than that in the control group,the number of lymph nodes resected was less,the differences were significant between the two groups（χ^2=25.694,t=4.818,P〈0.05）.The rest operation-related parameters and complications between the two groups were not statistically significant（P〉0.05）. Conclusion Preoperative chemoradiation followed by laparoscopic surgery for rectal cancer is safe and feasible,which does not increase postoperative complications.

关 键 词：直肠肿瘤 放化疗 辅助 腹腔镜 

分 类 号：R735.37[医药卫生—肿瘤]