生长受限胎儿脑损害及产前干预  

Fetal brain development：adverse effects of intrauterine growth restriction and antenatal intervention Wang Yan,Liu Jing. Department of Neonatology and Neonatal Intensive Care Unit of Bayi Children＆#39;s Hospital,Beijing Military General Hospital,Beijing 100700,China

作　　者：王燕[1] 刘敬[1] 

机构地区：[1]北京军区总医院附属八一儿童医院新生儿重症监护中心,100700

出　　处：《中华实用儿科临床杂志》2015年第14期1041-1045,共5页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金（81170577,81471087）

摘　　要：胎儿时期是脑发育的关键时期，宫内生长受限（IUGR）不仅影响胎儿体质量与身长增长，而且也严重危害胎儿脑发育，并导致远期神经行为异常。由于生长受限胎儿的脑损害起始于宫内，出生后的干预难以彻底改善患儿预后，故加强产前干预是最佳途径，其中孕期补充牛磺酸具有重要价值。现就 IUGR 对胎儿脑发育的不良影响及产前干预的情况予以介绍，以期最大限度改善患儿神经系统预后。The fetal stage is a critical period for brain development. Intrauterine growth restriction（IUGR）af-fects the growth of fetus and impairs the brain development severely,resulting in long - term neurological sequelae such as motor and behavioral disorders. Since their brain underdevelopment originated in the uterus,postnatal interventions usually fail to improve the brain function. Then antenatal interventions become urgent to protect the brain,taurine has appeared a high practical value in improving the brain development. The adverse effects of IUGR on fetal brain develop-ment and the possibilities of antenatal interventions were introduced in this paper in order to improve the prognosis of the nervous system.

关 键 词：生长受限 胎儿 脑发育 神经行为异常 牛磺酸 产前干预 

分 类 号：R714.5[医药卫生—妇产科学]