急性脑梗死尿激酶溶栓后联合肝素抗凝治疗的临床研究  

Anticoagulant Therapy of Acute Cerebral Infarction after Urokinase Thrombolysis Clinical Studies

作　　者：崔玉凤[1] 张海英[1] 关标 

机构地区：[1]哈尔滨二四二医院,哈尔滨150066

出　　处：《航空航天医学杂志》2015年第7期796-797,共2页Journal of Aerospace medicine

摘　　要：目的观察急性脑梗死尿激酶溶栓后联合抗凝治疗的疗效及安全性。方法 62例急性脑梗死病人根据尿激酶溶栓后是否抗凝治疗分为抗凝组和非抗凝组两组,每组31例。入选的62例病人均给予尿激酶溶栓治疗。抗凝组31例溶栓后复查凝血象,根据APTT值给予肝素钠50 mg^100 mg静脉滴注,7~10天后改口服阿司匹林。非抗凝组31例尿激酶溶栓24 h后给予口服阿司匹林。根据NIHSS评分及mRS评分比较两组治疗效果。结果抗凝组的疗效优于非抗凝组(P<0.05)。结论急性脑梗死发病后6h内静脉注射尿激酶是安全有效的,且尿激酶溶栓后给予肝素抗凝治疗更有助于急性脑梗死患者在急性期的神经功能恢复。Objective To observe the acute cerebral infarction after urokinase thrombolysis efficacy and safety of an- ticoagulant therapy. Methods 34 cases of acute cerebral infarction patients according to whether to use anticoagulant therapy is divided into anticoagulation after urokinase thrombolysis group and non anticoagulation in the two groups, each group of 17 cases. Were performed in 34 patients urokinase thrombolysis treatment, thrombolysis for review within 24 hours after head CT, cerebral hemorrhage. Antieoagulation after the group of 17 cases of thrombolysis review less regres- sion, such as AP＇I3＇ normal given heparin 50 mg to 100 mg intravenous drip, 7 ~ 10 days after oral aspirin instead. The anticoagulant group of 17 cases of urokinase thrombolysis for 24 h after oral aspirin. Application of statistical methods re- spectively to compare the curative effect of anticoagulant and anticoagulation group, according to the NIHSS score com- parison of the two groups after treatment. Results The curative effect of anticoagulant group is better than that of the an- ticoagulant group （ P 〈 0.05 ）. Conclusions The onset of acute cerebral infarction within 6 hours after intravenous uro- kinase is safe and effective, and anticoagulant therapy is administered after urokinase thrombolysis more helpful in pa- tients with acute cerebral infarction in acute stage of neural functional recovery.

关 键 词：急性脑梗死 尿激酶 抗凝 

分 类 号：R743.33[医药卫生—神经病学与精神病学]