甘露醇右旋糖酐40在家兔体内的PK-PD模型研究  

PK-PD model of dextran 40 and mannitol in rabbits

作　　者：谭然然[1] 金青[1] 李冉[1] 陈传秀[1] 王兴娜[1] 

机构地区：[1]青岛科技大学化工学院,青岛266042

出　　处：《西北药学杂志》2015年第4期397-400,共4页Northwest Pharmaceutical Journal

摘　　要：目的研究右旋糖酐40甘露醇复方注射剂和甘露醇单方注射剂中甘露醇的药动学及药效学关系,建立其在家兔体内的PK-PD(药动-药效)模型。方法采用气相色谱法测定血样中甘露醇的质量浓度,以规定时间内家兔排尿量作为甘露醇利尿效应指标。结果甘露醇静注给药后其药时曲线符合二室模型,单方组和复方组均出现最大利尿效应滞后于血药质量浓度的现象,复方组药效明显高于单方组;甘露醇的药理效应和效应室质量浓度的关系符合Sigmoid-Emax模型,且该模型所得预测药效值与实测药效值接近。结论建立的PK-PD模型预测所得甘露醇静注给药后的血药质量浓度及药理效应准确可靠,为改善临床应用提供理论依据。Objective To study the pharmacokinetics and pharmacodynamics of mannitol after Mannitol Injections and Compound Mannitol Injections prescribed,and to establish the PK-PD model of intravenous administration.Method The concentrations of mannitol in plasma were detected by GC and the output urine volume was taken as indexes to analyze the diuretic effect of mannitol.Results The plasma concentration-time curves of mannitol fitted to double chamber model;The delayed effects were existed between diuretic effects and drug concentration,and pharmacological effect of drug combination was stronger than that of single drug;Relationship between efficacy and chamber concentration accorded with Sigmoid-Emax model,and the predicted values of this model were close to the experimental values.Conclusion This PK-PD model could accurately predict the plasma concentration and therapeutic effects of mannitol after intravenous injection,providing reliable theory basis for improving clinical administration.

关 键 词：PK-PD结合模型 甘露醇 Sigmoid-Emax模型 右旋糖酐40 

分 类 号：R945[医药卫生—微生物与生化药学]