丁苯酞联合尼莫地平治疗血管性认知功能障碍的临床观察  

Clinical Observation of Butylphthalide Combined with Nimodipine in the Treatment of Vascular Cognitive Impairment

作　　者：姜霁纹[1] 刘水平[1] 李晓晴[1] 李丛佳[1] 

机构地区：[1]首都医科大学附属北京安贞医院神经内科,北京100029

出　　处：《中国药房》2015年第21期2909-2911,共3页China Pharmacy

摘　　要：目的:观察丁苯酞联合尼莫地平治疗血管性认知功能障碍(VCI)的疗效和安全性。方法:将156例VCI患者随机均分为对照组与观察组。所有患者均给予抗血小板、控制血压、降血糖、他汀类药降脂、稳定斑块等常规治疗。在此基础上,对照组患者给予尼莫地平片30 mg,口服,每日3次;观察组患者在对照组治疗的基础上给予丁苯酞软胶囊0.2 g,口服,每日3次。两组患者疗程均为3个月。观察两组患者的临床疗效,治疗前后蒙特利尔认知评估量表(Mo CA)评分、日常生活能力量表(ADL)评分、狭窄大血管远端血流速度及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者Mo CA评分、ADL评分、狭窄大血管远端血流速度均显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:在常规治疗的基础上,丁苯酞联合尼莫地平治疗VCI及血管重构较单用尼莫地平疗效更显著,可更好地改善狭窄大血管远端的血流速度,安全性相当。OBJECTIVE：To investigate the clinical efficacy and safety of butylphthalide combined with nimodipine in the treatment of vascular cognitive impairment. METHODS：Totally 156 patients with vascular cognitive impairment were randomly divided into control group and observation group. All patients were given anti-platelet,control of blood pressure,lowering blood glucose,lowering statin therapy for stable plaque and symptomatic treatment. On this basis,control group was orally treated with nimodipihe 30 mg,tid;observation group was orally treated with Butylphthalide capsule 0.2 g based on the treatment of control group,tid.The course lasted for 3 months. The clinic data was observed,including clinical efficacy,and Montreal cognitive assessment（MoCA）score,activities of daily living scale（ADL）score,stenosis great vessels distal blood flow velocity and incidence of adverse reactions before and after treatment. RESULTS：The total effective rate in observation group was significantly higher than control group,with significant difference（P〈0.05）. After treatment,the Mo CA score,ADL score and stenosis great vessels distal blood flow velocity in 2 groups were significantly higher than before,and observation group was higher than control group,with significant differences（P〈0.05）. There were no obvious adverse reactions during treatment. CONCLUSIONS：Based on the conventional treatment,butylphthalide combined with nimodipine has better efficacy than nimodipine alone in the treatment of vascular cognitive impairment,and can improve the stenosis great vessels distal blood flow velocity better,with similar safety.

关 键 词：血管性认知功能障碍 丁苯酞 尼莫地平 血流速度 

分 类 号：R743[医药卫生—神经病学与精神病学]