血清补体在脂肪肝患者脂质代谢紊乱中的变化情况及其临床意义  

Study on the changes of complement and its clinical significan in patients with fatty liver disease

作　　者：王艳斌[1] 谢雯[1] 张婷[1] 闫杰[1] 王京京[1] 赵红[1] 范颖[1] 程澄[1] 

机构地区：[1]首都医科大学附属北京地坛医院肝病中心,北京100015

出　　处：《中国实验诊断学》2015年第7期1088-1091,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的了解脂肪肝(Fatty liver disease,FLD)患者血清补体的变化情况及其临床意义。方法收集2008年5月至2013年9月在我院收治的500例FLD患者(观察组),另选同期健康体检者500例(对照组),检测血脂水平及采用免疫散射比浊法测定血清补体C3、C4、C5和BF含量。结果观察组TC、TG、LDL-C和HDL-C均值水平与对照组相比显著增高(P<0.01或P<0.05)。观察组血清C3、C5和BF水平较对照组均有不同程度的升高,两组比较差异均具有统计学意义(P<0.01或P<0.05),而C4含量稍有升高,但两者比较差异无统计学意义(P>0.05)。对照组和观察组的C3、C5和BF增高病例分别有27例(5.4%)和375例(75.0%)、53例(10.6%)和326例(65.2%)、22例(44.0%)和273例(54.6%),两组间比较显著差异,具有统计学意义(P<0.01)。对照组和观察组的C3、C5和BF分别在TC、TG、LDL-C和HDL-C值异常方面比较均具有显著差异(P<0.01)。结论 FLD患者血清补体C3、C5和BF含量明显增高,对FLD患者的病情诊断评估和预后判断有一定参考意义。Objective To explore the changes of complement and its clinical significan in patients with fatty liver disease（fatty liver disease,FLD）.Methods 500 patients with FLD（observation group）and 500 healthy subjects（control group）collected from hospital were enrolled in the study from May 2008 to September 2013.The level of lipid was examined,and the content of complement C3,C4,C5,and BF was detected in two groups by using the scattering immunoturbidimetric assay.Results Compared with the control group,the level of TC,TG,LDL-C,and HDL-C in the observation group were significantly increased（P〈0.01 and P〈0.05）,as well as the content of complement C3,C5,and BF（P〈0.01 and P〈0.05）.But there was no significant difference in the content of complement C4 between the two groups（P〉0.05）.Cases with increasing of C3,C5,and BF in control group and observation group were 27（5.4%）and 375（75.0%）,53（10.6%）and 326（65.2%）,and 22（44.0%）and 273（54.6%）,respectively.There was significant difference between two groups（P〈0.01）.The changes of C3,C5,and BF have statistical significance on the disorder of TC,TG,LDL-C,and HDL-C between two groups（P〈0.01）.Conclusion The content of complement C3,C5,and BF were significantly increased in FLD,which has certain reference value for the assessment,diagnosis and prognosis of patient with FLD.

关 键 词：脂肪肝 补体 脂质 代谢紊乱 

分 类 号：R575.5[医药卫生—消化系统]