igh-frequency Oscillations and the Seizure Onset Zones in Neocortical Epilepsy  

作　　者：Yan-Ping Sun Yu-Ping Wang Zhi-Hong Wang Feng-Yu Wu Li-Ou Tang Shou-Wen Zhang Hai-Tao Pei Yan Wang Zhao-Yang Huang Qing Xue Cui-Ping Xu Jun-Li Tai 

机构地区：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beiiing 100053, China [2]DePartment of NeuroloQv, The Affiliated Hospital of Qincldao Universitv, Qinadao, ShandonQ 266003, China [3]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China [4]Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China [5]Epilepsy Department, Beijing Chaoyang Emergency Hospital, Beijing 101149, China [6]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [7]Depariment of Functional Neurosurgery~ Beijing Luhe Hospital, Capital Medical University, Beijing 100122, China

出　　处：《Chinese Medical Journal》2015年第13期1724-1727,共4页中华医学杂志（英文版）

摘　　要：Background： To study the characters of high-frequency oscillations （HFOs） in the seizure onset zones （SOZ） and the nonseizure onset zones （NSOZ） in the electrocorticography （ECoG） of patients with neocortical epilepsy. Methods： Only patients with neocortical epilepsy who were seizure-free after surgery as determined with ECoG were included. We selected patients with normal magnetic resonance imaging before surgery in order to avoid the influence of HFOs by other lesions. Three minutes preictal and 1 0 rain interictal ECoG as recorded in 39 channels in the SOZ and 256 channels in the NSOZ were analyzed. Ripples and fast ripples （FRs） were analyzed by Advanced Source Analysis soltware （ASA, The Netherlands）. Average duration of HFOs was analyzed in SOZ and NSOZ separately. Results： For ripples, the permillage time occupied by HFOs was 0.83 in NSOZ and 1.17 in SOZ during the interictal period. During preictal period, they were 2.02 in NSOZ and 7.93 in SOZ. For FRs, the permillage time occupied by HFOs was 0.02 in NSOZ and 0.42 in SOZ during the interictal period. During preictal period, they were 0.03 in NSOZ and 2 in SOZ. Conclusions： High-frequency oscillations are linked to SOZ in neocortical epilepsy. Our study demonstrates the prevalent occurrence of HFOs in SOZ. More and more burst of HFOs, especially FRs, means the onset of seizures.Background： To study the characters of high-frequency oscillations （HFOs） in the seizure onset zones （SOZ） and the nonseizure onset zones （NSOZ） in the electrocorticography （ECoG） of patients with neocortical epilepsy. Methods： Only patients with neocortical epilepsy who were seizure-free after surgery as determined with ECoG were included. We selected patients with normal magnetic resonance imaging before surgery in order to avoid the influence of HFOs by other lesions. Three minutes preictal and 1 0 rain interictal ECoG as recorded in 39 channels in the SOZ and 256 channels in the NSOZ were analyzed. Ripples and fast ripples （FRs） were analyzed by Advanced Source Analysis soltware （ASA, The Netherlands）. Average duration of HFOs was analyzed in SOZ and NSOZ separately. Results： For ripples, the permillage time occupied by HFOs was 0.83 in NSOZ and 1.17 in SOZ during the interictal period. During preictal period, they were 2.02 in NSOZ and 7.93 in SOZ. For FRs, the permillage time occupied by HFOs was 0.02 in NSOZ and 0.42 in SOZ during the interictal period. During preictal period, they were 0.03 in NSOZ and 2 in SOZ. Conclusions： High-frequency oscillations are linked to SOZ in neocortical epilepsy. Our study demonstrates the prevalent occurrence of HFOs in SOZ. More and more burst of HFOs, especially FRs, means the onset of seizures.

关 键 词：ELECTROCORTICOGRAPHY EPILEPSY High-frequency Oscillations Seizure Onset Zones 

分 类 号：TS211.4[轻工技术与工程—粮食、油脂及植物蛋白工程] TM320.71[轻工技术与工程—食品科学与工程]