he Natural Progression of Parkinson＇s Disease in a Small Cohort with 15 Drug-na＇~＇ve Patients  

作　　者：Ying Liu Jin-Hu Fan Xiang Gao Li Ma You-Lin Qiao Lin Zhang 

机构地区：[1]Department of Neurology, Dalian Municipal Friendship Hospital, Dalian, Liaoning 116001, China [2]Department of Cancer Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China [3]Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA [4]Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA [5]Department of Epidemiology, Dalian Medical University, Dalian, Liaoning 116044, China [6]Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA

出　　处：《Chinese Medical Journal》2015年第13期1761-1764,共4页中华医学杂志（英文版）

摘　　要：The studies of the natural progression of Parkinson＇s disease （PD） in Chinese populations have been lacking. To address this issue and obtain a preliminary data, we conducted a PD progression assessment in 15 adults with de novo PD from a nutritional intervention trial （NIT） cohort in Lin County China. Methods： Using the Copiah County screening questionnaire and United Kingdom Parkinson＇s Disease Society Brain Bank diagnostic criteria, we surveyed the available N IT cohort members in 2000 and diagnosed 86 patients as PD. In 2010, we resurveyed all PD patients and confirmed definite PD diagnosis in 15 cases with the rest of them being dead （54）： having probable （10） PD or vascular Parkinsonism （3）; relilsing to participate （2）; or being away （2）. In both surveys, we used Hoehn and Yahr （HY） scale and assessed the disease progression. Unified Parkinson＇s Disease Rating Scale （UPDRS） was added to the second survey. Results： In 2010, the average disease duration for 15 definite PD patients was 13.6 ~ 7.3 years. Over a 10-year time span, 9 out of 15 patients remained at the same HY stage while the remaining 6 progressed. Rigidity （47% vs. 100%; P 0.002） and postural instability （7% vs. 47%; P - 0.005） worsened significantly. The mean UPDRS motor scores in 2010 were 39.4 ± 23.7. Conclusions： Overall worsening of motor timction in PD seems to be the rule in this untreated cohort, and their rate of progression seemed to be slower than those reported in the western populations.The studies of the natural progression of Parkinson＇s disease （PD） in Chinese populations have been lacking. To address this issue and obtain a preliminary data, we conducted a PD progression assessment in 15 adults with de novo PD from a nutritional intervention trial （NIT） cohort in Lin County China. Methods： Using the Copiah County screening questionnaire and United Kingdom Parkinson＇s Disease Society Brain Bank diagnostic criteria, we surveyed the available N IT cohort members in 2000 and diagnosed 86 patients as PD. In 2010, we resurveyed all PD patients and confirmed definite PD diagnosis in 15 cases with the rest of them being dead （54）： having probable （10） PD or vascular Parkinsonism （3）; relilsing to participate （2）; or being away （2）. In both surveys, we used Hoehn and Yahr （HY） scale and assessed the disease progression. Unified Parkinson＇s Disease Rating Scale （UPDRS） was added to the second survey. Results： In 2010, the average disease duration for 15 definite PD patients was 13.6 ~ 7.3 years. Over a 10-year time span, 9 out of 15 patients remained at the same HY stage while the remaining 6 progressed. Rigidity （47% vs. 100%; P 0.002） and postural instability （7% vs. 47%; P - 0.005） worsened significantly. The mean UPDRS motor scores in 2010 were 39.4 ± 23.7. Conclusions： Overall worsening of motor timction in PD seems to be the rule in this untreated cohort, and their rate of progression seemed to be slower than those reported in the western populations.

关 键 词：Drug-naive EPIDEMIOLOGY Parkinson＇s Disease PROGRESSION 

分 类 号：Q593.2[生物学—生物化学] TP311.12[自动化与计算机技术—计算机软件与理论]