血清促炎细胞因子白介素-6与急性胰腺炎严重程度的相关性  

Correlation between serum levels of interleukin-6 and severity of acute pancreatitis

作　　者：聂军[1] 

机构地区：[1]遵义市第一人民医院消化内科,贵州省遵义市563002

出　　处：《世界华人消化杂志》2015年第17期2816-2819,共4页World Chinese Journal of Digestology

摘　　要：目的:研究血清促炎细胞因子白介素(interleukin,IL)-6与急性胰腺炎(acute pancreatitis,AP)严重程度的相关性.方法:选择遵义市第一人民医院重症AP(severe acute pancreatitis,SAP)患者138例作为SAP组.另选同期轻度AP(mild acute pancreatitis,MAP)患者126例作为MAP组.选择同期在遵义市第一人民医院进行健康体检的志愿者150例作为对照组.检测并对比各组血清IL-6指标水平,并记录并发症情况,分析患者血清IL-6指标水平与Ranson评分的相关性.分析影响AP疾病严重程度的危险因素.结果:SAP组的IL-6及Ranson评分水平均显著高于MAP组及对照组;SAP组中的有并发症组患者的IL-6及Ranson评分均显著高于无并发症组(均P<0.05).根据Spearman法分析相关性可知,患者血清IL-6指标水平与Ranson评分均呈正相关.将AP严重程度作为因变量,将患者年龄、性别、高Ranson评分及高IL-6水平作为自变量,经Logistic回归分析可知,高IL-6水平均为AP严重程度的危险因素.结论:IL-6与AP严重程度联系紧密,临床上应重视此情况,给予相应的监测.AIM：To assess the correlation between serum levels of interleukin（IL-6） and the severity of acute pancreatitis（AP）.METHODS：This study included 138 patients with severe AP（SAP）,126 with mild AP（MAP）,and 150 healthy volunteers who underwent physical examination（control group）.Serum levels of IL-6 in each group were detected and compared.The complications were recorded.The correlation between serum levels of IL-6and Ranson score was analyzed,and the risk factors for the severity of AP were analyzed.RESULTS：IL-6 level and Ranson score in the SAP group were both significantly higher than those in the MAP group and control group.IL-6 level and Ranson score in SAP patients with complications were significantly higher than those in SAP patients without complications（P〈0.05）.Spearman correlation analysis showed that serum levels of IL-6 had a positive correlation with Ranson score.Using the severity of AP as the dependent variable,and age,gender,high Ranson score and high IL-6 level as the independent variables,we performed Logistic regression analysis and found that high IL-6 level was a risk factor for the severity of AP.CONCLUSION：IL-6 is closely linked to the AP severity.

关 键 词：血清 促炎细胞因子 白介素-6 急性胰腺炎 严重程度 相关性 

分 类 号：R576[医药卫生—消化系统]