中药灌肠对轻、中度溃疡性结肠炎患者的疗效及脂联素的调节作用  

Chinese medicine enema for treatment of patients with mild to moderate ulcerative colitis:Therapeutic effect and regulatory effect on adiponectin

作　　者：何显[1] 张清泉[2] 王真 王文智[4] 王丽华[1] 

机构地区：[1]衡水市哈励逊国际和平医院消化科,河北省衡水市053000 [2]衡水市哈励逊国际和平医院病理科,河北省衡水市053000 [3]衡水市第三人民医院检验科,河北省衡水市053000 [4]衡水市哈励逊国际和平医院检验科,河北省衡水市053000

出　　处：《世界华人消化杂志》2015年第17期2834-2838,共5页World Chinese Journal of Digestology

摘　　要：目的:观察中药灌肠对轻、中度溃疡性结肠炎(ulcerative colitis,UC)患者临床疗效及脂联素的调节.方法:采用分层随机化分组,将符合入组标准的106例轻、中度UC患者分为观察组和对照组,两组患者均给予美沙拉嗪肠溶片,在此基础上观察组给予中药灌肠.治疗4w k后评价2组患者实验室指标、疾病活动指数和肠黏膜脂联素的变化,并记录不良反应.结果:两组患者无病例脱落及失访;治疗后两组患者实验室指标、疾病活动指数和肠黏膜脂联素水平均较治疗前有明显改善,观察组较对照组改善更为显著(P<0.05).结论:中药保留灌肠联合美沙拉嗪治疗轻、中度UC比单用美沙拉嗪肠溶片有较好的疗效,且不良反应率低.AIM：To observe the clinical effects of traditional Chinese medicine enema in patients with mild to moderate ulcerative colitis（UC） and its effect on adiponectin levels.METHODS：A stratified randomized clinical trial was carried out.A total of 106 patients with UC were divided into two groups：an observation group and a control group.Patients in the observation group（n = 53） were given mesalazine and traditional Chinese medicine enema,while patients in the control group（n-53） were given mesalazine only.The period of treatment was 4 wk.The adiponectin levels in patients with UC,disease activity index（DAI） and laboratory indicators were evaluated,and adverse reactions were recorded.RESULTS：No case dropped out.The adiponectin level,disease activity index and laboratory indicators showed a significant decrease in both groups after treatment,and the decrease was more significant in the observation group.CONCLUSION：Combination of traditional Chinese medicine enema and mesalazine is more effective and has fewer adverse effects than mesalazine alone in the treatment of patients with mild to moderate UC.

关 键 词：溃疡性结肠炎 脂联素 美沙拉嗪 中药 

分 类 号：R574.62[医药卫生—消化系统]