超声引导下经皮肝穿刺注射华蟾素治疗原发性肝癌伴门静脉癌栓的临床效果  

Ultrasound-guided percutaneous cinobufagin injection for treatment of portal vein tumor thrombus in primary liver cancer patients

作　　者：冀建峰[1] 邓晓莉[1] 肖秋金[1] 杨雪[2] 

机构地区：[1]解放军第九四医院,南昌330002 [2]江西省儿童医院,南昌330006

出　　处：《临床肝胆病杂志》2015年第6期899-902,共4页Journal of Clinical Hepatology

基　　金：江西省卫生厅中医药科研基金课题(2013A044)

摘　　要：目的探讨超声引导下经皮肝穿刺注射华蟾素治疗门静脉癌栓的临床应用价值。方法选取2009年1月-2012年3月解放军第九四医院收治的25例原发性肝癌伴门静脉癌栓患者,行超声引导下经皮肝门静脉穿刺注射华蟾素,每周3次,4～5周为一个疗程,治疗后观察患者的临床疗效及生存期,并比较其治疗前后的甲胎蛋白（AFP）、ALT水平。计量资料比较采用t检验。结果17例门静脉癌栓患者不同程度缓解,总有效率为68%,患者AFP及ALT水平降低,差异具有统计学意义（P〈0.05）。治疗后随访3、6、12、24个月生存率分别为88%、76%、60%、32%。结论超声引导下经皮肝穿刺注射华蟾素对门静脉癌栓疗效肯定,有较好的临床使用价值。Objective To evaluate the clinical value of ultrasound- guided percutaneous cinobufagin injection for the treatment of portal vein tumor thrombus（ PVTT） in primary liver cancer（ PLC） patients. Methods A total of 25 PLC patients with PVTT who were admitted to our hospital from January 2009 to March 2012 were recruited in this study. These patients underwent ultrasound- guided percutaneous cinobufagin injection three times a week,and each course of treatment was 4- 5 weeks. After treatment,the clinical efficacy and survival rates were determined,and the changes in levels of alpha fetoprotein（ AFP） and alanine aminotransferase（ ALT） were evaluated. Results Seventeen patients showed varying degrees of improvement after treatment,with an overall response rate of 68%. In addition,the levels of AFP and ALT were significantly reduced after treatment（ P〈0. 05）. The survival rates at 3,6,12,and 24 months after treatment were88%,76%,60%,and 32%,respectively. Conclusion Ultrasound- guided percutaneous cinobufagin injection has good efficacy in the treatment of PVTT in PLC patients and shows a good clinical value.

关 键 词：肝肿瘤 门静脉癌栓 超声检查 介入性 华蟾蜍毒素 

分 类 号：R735.7[医药卫生—肿瘤]