c-Met在肝细胞癌发生发展中的作用  

Research progress in c-Met and hepatocellular carcinoma

作　　者：王长青[1,2] 郭薇薇[1,2] 刘政[1,2] 

机构地区：[1]南京医科大学第二临床医学院 [2]南京医科大学第二附属医院消化医学中心,南京210011

出　　处：《临床肝胆病杂志》2015年第6期982-984,共3页Journal of Clinical Hepatology

摘　　要：c-Met在肝细胞癌的发生、发展中起着关键作用,可导致肿瘤细胞的增殖、存活、细胞骨架重组、分离扩散及血管生成等,同时还是评价预后的一个重要指标。c-Met在肝细胞癌中主要通过激活一系列信号通路发挥作用。近年来提出的小分子激酶抑制剂可阻止c-Met胞内羧基末端磷酸化,进而阻止信号转换器的募集及下游信号通路的传导,从而发挥抗肿瘤作用。基于对cMet的了解及其在肝细胞癌中的致癌作用,指出了选择性c-Met抑制剂靶向治疗肝细胞癌的应用前景。c- Met plays a pivotal role in the development and progression of hepatocellular carcinoma（ HCC）,which can lead to proliferation,survival,cytoskeleton reorganization,separation and diffusion,and angiogenesis of tumor cells. Moreover,c- Met is an important prognostic factor for HCC. In HCC,c- Met acts as an activator of a series of signaling pathways,including PI3 K / AKT / m TOR,ERK /MAPK,and Rac- Pak. In recent years,it has been reported that small- molecule kinase inhibitors can abolish phosphorylation at the intracellular carboxyl terminal of c- Met,and then inhibit the recruitment of signal convertors and downstream signaling pathways,which finally achieve anti- tumor activities. Based on the carcinogenic activity of c- Met in HCC,this paper points out that selective inhibitors of c- Met hold promise for targeted therapies for HCC.

关 键 词：癌 肝细胞 原癌基因蛋白质C-MET 信号传导 综述 

分 类 号：R735.7[医药卫生—肿瘤]