从调控肝再生探讨肝纤维化的防治  

Prevention and treatment of liver fibrosis by regulating liver regeneration

作　　者：李瀚旻[1] 

机构地区：[1]湖北中医药大学附属医院肝病研究所,国家中医药科研细胞分子生物学三级实验室,武汉430061

出　　处：《临床肝胆病杂志》2015年第6期992-995,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81373513;90709041;30672590;30271562;30371787;81102531;81274147);国家科技部重大基础研究项目("973"项目;2002CCC00300);国家"十二五"重大专项(2012ZX10005005-001-015);国家中医临床研究基地(湖北)重点病种研究项目(JDZX2012054);湖北省自然科学基金重点项目(2011CDB463);高等学校博士学科点专项科研基金项目(20124230110001);武汉市科技局科技攻关武汉市重大科技产业化专项项目(201260523199)

摘　　要：肝纤维化是肝再生紊乱的一种形式或状态。从调控肝再生的新视角探讨肝纤维化的防治,可以提出新的防治策略与方法:关注对抗性反向调节,更强调正向诱导;综合运用促进与抑制策略,改善肝损伤与肝再生,异常肝再生与正常肝再生失调;主张防治结合,防肝纤维化的发生或乱生,治肝纤维化的过亢进展。CCl4诱导的大鼠肝纤维化模型存在上皮-间质转型(EMT)/间质-上皮转型(MET)失衡的异常肝再生机制,地五养肝胶囊能延缓肝纤维化的病程进展,并减轻纤维化的程度,其作用机制之一是通过调节EMT/MET失衡(抑制EMT而促进MET)而改善肝再生过程。Liver fibrosis is regarded as a form or status of liver regeneration disorder. Therefore,from a new perspective of regulating liver regeneration,we put forward a new strategy for the prevention and treatment of liver fibrosis. This strategy not only focuses on confrontational reverse regulation,but also emphasizes positive induction. Moreover,this strategy applies an integrated method of promotion and inhibition,which improves liver injury and regeneration and corrects the abnormal liver regeneration and the normal liver regeneration disorder. Furthermore,this strategy also advocates the combination of prevention and treatment,which prevents the occurrence of liver fibrosis or a disorder of liver regeneration and treats the rapid progression of liver fibrosis. The imbalance between epithelial- mesenchymal transition（ EMT） and mesenchymal- epithelial transition（ MET） is involved in the CCl4- induced liver fibrosis in rats. Diwu Yanggan capsules can delay the progression of liver fibrosis and attenuate the degree of fibrosis,which is associated with the regulation of liver regeneration by modulating the imbalance between EMT and MET（ inhibiting EMT and / or promoting MET）.

关 键 词：肝硬化 肝再生 中药疗法 综述 

分 类 号：R575.2[医药卫生—消化系统]