拉坦前列腺素对原发性开角型青光眼患者的疗效  

The Curative Effect of Latanoprost on Patients with Primary Open-angle Glaucoma

作　　者：高文清[1] 

机构地区：[1]广元市第一人民医院,四川广元628017

出　　处：《贵阳医学院学报》2015年第7期760-762,共3页Journal of Guiyang Medical College

摘　　要：目的:研究拉坦前列腺素对原发性开角型青光眼(POAG)患者的治疗效果。方法:POAG患者135例,随机分为观察组(n=70)和对照组(n=65),观察组给予拉坦前列腺素治疗,对照组给予噻吗心安治疗;记录2组患者治疗前后的眼压及波动值、视野缺损及视网膜纤维层(RNFL)厚度及不良反应。结果:两组患者治疗后昼夜平均眼压、眼压波动值及视野缺损范围均较治疗前明显降低,差异有统计学意义(P<0.05);治疗后观察组昼夜平均眼压、眼压波动值较对照组降低更明显,下方视野、颞侧视野及鼻侧视野缺损范围较对照组明显缩小,上方视盘、下方视盘、颞侧视盘及鼻侧视盘较对照组明显增厚,差异均有统计学意义(P<0.05);治疗后观察组9例(12.86%)、对照组11例(16.92%)出现不良反应,差异无统计学意义(P>0.05)。结论:拉坦前列腺素治疗原发性开角型青光眼效果优于噻吗心安。Objective： To observe the effect of latanoprost on patients with primary open -angle glau- coma. Methods：A total of 135 patients with primary open - angle glaucoma were enrolled in this stud- y. All the cases were randomly divided into observation group and control group. The observation group （70 cases） were treated with latanoprost while the control group （65 cases） were treated with timolol maleate. The IOP, visual field defects as well as the thickness of the retinal fiber layer （ RN- FL） were measured and recorded. And the untoward effects were also observed. Results：After treat- ment, 24 h mean IOP, IOP fluctuation value and the extent of visual field defects in two group were significantly decreased, and the differences between before treatment and after treatment were statisti- cally significant （P 〈 0. 05 ）. Compared with control group, after treatment, 24 h mean IOP, IOP fluctuation value decreased more significantly, the extent of below visual field defect, temporal visual field defect and nasal visual field defect significantly reduced, and above optic disc, below optic disc, temporal optic disc and nasal optic disc significantly thickened in observation group （ P 〈 0.05 ）. There were 9 cases （12.86%） adverse reactions in observation group while 1t cases （16.92%） in control group, and the differences were not statistically significant （P 〉 0. 05 ）. Conclusion： Latano- prost is better than timolol maleate in treatment of primary open -angle glaucoma.

关 键 词：拉坦前列腺素 噻吗心安 青光眼 开角型 原发性 眼压 视盘 

分 类 号：R775.2[医药卫生—眼科]