β-catenin在乳腺癌中的不同表达定位与预后的关系  

Different expression pattern of β-catenin in breast cancer and relationship with prognosis

作　　者：孙明立[1] 赵海山[1] 肖庆环 于兆进[1] 姚维凡[1] 唐宏涛[1] 关舒[3] 金锋[3] 魏敏杰[1] 

机构地区：[1]中国医科大学药学院药理教研室,辽宁沈阳110122 [2]中国医科大学药学院离子通道研究室,辽宁沈阳110122 [3]中国医科大学附属第一医院乳腺外科,辽宁沈阳110001

出　　处：《热带医学杂志》2015年第6期717-720,F0003,共5页Journal of Tropical Medicine

基　　金：国家自然科学基金面上资助项目(81373427)

摘　　要：目的探讨β-连环蛋白(β-catenin)在乳腺癌中的不同表达定位与临床病理特征及预后的关系。方法采用免疫组化方法检测271例乳腺癌患者中β-catenin的表达,并分析其不同表达定位与临床病理特征及预后的关系。结果 271例乳腺癌中有196例β-catenin呈阳性表达,阳性表达率为72.3%,其中87例(44.4%)为胞浆表达,109例(55.6%)为胞膜表达。β-catenin表达定位与乳腺癌淋巴结转移及组织学分级呈正相关(P=0.002和P=0.014),而与年龄、绝经状态、肿瘤大小、肿瘤类型、临床分期无关(P>0.05)。Kaplan-Meier生存分析显示β-catenin胞浆表达的乳腺癌患者总生存期(OS)和无病生存期(DFS)明显短于其胞膜表达的患者,差异有统计学意义(P=0.015和P=0.023)。Cox比例风险回归分析显示β-catenin表达定位是影响乳腺癌患者预后的危险因素(P=0.025和P=0.014),但不是独立危险因素(P=0.546和P=0.919)。结论β-catenin在乳腺癌中的不同表达定位提示不同的预后价值,β-catenin在乳腺癌细胞浆中表达可作为肿瘤预后不良的一个参考指标。Objective To study the different expression pattern of β-catenin in breast cancer and clinical significance.Methods The expression of β-catenin protein in 271 breast cancer tissues was detected by immunohistochemistry and its relationship with clinicopathological factors and prognosis were analyzed. Results β-catenin was mainly expressed in cytoplasm and membrane, with an expression rate of 72.3%（196 / 271） in breast breast carcinoma tissues, including109 membrane expression and 87 cytoplasm expression. The expression of β-catenin protein was positively related to lymph node metastasis（P =0.002） and histological grade（P =0.014）, but no relationship with age, menopause state,tumor size, tumor type and TNM stage（P〉 0.05）. There was significant difference of the disease-free survival（DFS） or overall survival（OS） between breast cancer patients with / without cytoplasm β-catenin expression（P =0.015 and P =0.023）. Cox proportional hazard regression analysis showed that β-catenin expression is the risk factors for prognosis of breast carcinoma, but not the independent prognostic factors. Conclusion Cytoplasm β-catenin expression in breast cancer tissues can be used as a reference index of poor prognosis of breast cancer.

关 键 词：乳腺癌 Β-连环蛋白 预后 定位 

分 类 号：R737.9[医药卫生—肿瘤]