压力对小梁网途径房水外流通路的影响  

The effect of pressure on trabecular aqueous humor outflow pathway

作　　者：宁利[1] 张宇燕[1] 

机构地区：[1]复旦大学附属华山医院眼科,上海200040

出　　处：《国际眼科纵览》2015年第3期180-184,共5页International Review of Ophthalmology

基　　金：上海市浦江人才计划（11PJD006）

摘　　要：病理性高眼压是原发性开角型青光眼（primary open-angle glaucoma,POAG）发病的重要危险因素之一,主要是由小梁网途径房水外流阻力增加所致.高眼压本身通过机械压力导致小梁网细胞老化、细胞骨架成分改变、细胞外基质异常沉积、氧化应激损伤、基因表达异常等影响小梁网途径房水外流阻力,这为探讨POAG的发病机制及治疗方向奠定了一定的基础.Pathological elevated intraocular pressure （IOP） is one of the major risk factors of primary open-angle glaucoma （POAG）,which is mainly due to the increased aqueous humor outflow resistance caused by trabecular meshwork change.High IOP is associated with cellular senescence,change of cytoskeleton,deposition of extracellular matrix,oxidative stress damage,and gene expression abnormality in trabecular aqueous humor outflow pathway through mechanical stress.It is important for investigating POAG pathophysiological mechanism and treatment options.

关 键 词：原发性开角型青光眼 压力 小梁网 房水流出道 

分 类 号：R775[医药卫生—眼科]