中关村破译致病基因超1500种健康风险将可预测  

The Expression Levels Study of Serotonin Transporter mRNA in the Acute Phase of Schizophrenia

作　　者：胡昌清[1,2] 杨杨[1] 陈静 丰雷[1,4] 史晓宁[1] 田腾飞[1] 甄龙[1] 王刚[1,5] 

机构地区：[1]首都医科大学附属北京安定医院抑郁症治疗中心,北京100088 [2]国家精神心理疾病临床医学研究中心(首都医科大学附属北京安定医院) [3]北京市怀柔安佳医院 [4]精神疾病诊断与治疗北京市重点实验室 [5]北京脑重大疾病研究院抑郁症研究所

出　　处：《中国医学创新》2015年第20期I0001-I0001,共1页Medical Innovation of China

摘　　要：治未病是指采取预防或治疗手段防止疾病发生、发展。根据每个人的健康状况不同，采取相应的个体化预防方案进行治未病，是古今中外医学界不断追求的梦想。如今，在中关村这一梦想正在变为现实。Objective： To study the differences of serotonin transporter （ SERT ） mRNA expression levels in peripheral leukocytes between acute phase of schizophrenia patients and healthy control. To study the gender differences in the SERT mRNA expression levels between two goUps. Method： 44 patients with acute phase of schizophrenia were selected in our hospital from May 2013 to November 2013, and then 42 healthy cases with the same age and gender were selected as the control group. The diagnosis of schizophrenia was established according to the DSM-IV-TR criteria. The severity of schizophrenia was assessed by the positive and negative syndromes scales （ PANSS ） .All subjects were interviewed using self-designed questionnaire on general information and tested by quantitative real-time PCR method in SERT mRNA levels.Result： SERT mRNA levels in leukecytes in acute phase of schizophrenia patients were significantly higher than that in control group, the difference was statistically significant （ P〈0.05 ） .Compared the SERT mRNA levels of two groups＇gender, the difference was no statistically significant （ P〉0.05 ） . Conclusion： The over expression of SERT mRNA levels may be one of the biomarkers of schizophrenia in acute phase.

关 键 词：中关村 致病基因 健康风险 破译 预测 疾病发生 健康状况 治未病 

分 类 号：R440[医药卫生—诊断学]