酯酶在化学合成中的应用进展  

Research progress on application of esterase in chemical synthesis

作　　者：帅慧慧 薛屏[1] 夏维涛 

机构地区：[1]宁夏大学省部共建天然气转化国家重点实验室培训基地,宁夏银川750021 [2]宁夏大学化学化工学院,宁夏银川750021

出　　处：《化学研究与应用》2015年第7期945-950,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21263020)资助;973计划前期研究专项项目(2012CB723106)资助

摘　　要：酯酶对于水解、酯化和转酯化等反应具有高活性和立体选择性,其生产成本低于脂肪酶,因而酯酶用作化学合成的催化剂,将使生物催化合成成本更低。分析了酯酶在分子合成中的催化性质,对酯酶催化手性分子和聚合物的合成及其固定化进行了总结和评述,并对其催化作用在化学合成方面的应用发展进行了展望。Esterase had excellent high stereo-selectivity and activity for hydrolysis,esterification and transesterification reaction. Esterase as catalysts for chemical synthesis would make the cost of biocatalysis lower than lipase. This review analyzed the catalytic properties and immobilization techniques of esterase,summarized the preparation of the chiral molecules and polymers catalyzed by esteraseand,and the new application and development of esterase in chemical synthesis as catalyst was viewed.

关 键 词：酯酶 酶催化 手性生物合成 固定化 

分 类 号：O643.3[理学—物理化学]