血管性认知功能障碍自我辨识筛查方案临床验证研究  

Clinical Validation of the Self-screening Program for Vascular Cognitive Impairment

作　　者：薛斐然[1] 张昕洋 牛焕敏 陈宝鑫[4] 姬少珍 贾蓓[2] 李涛[2] 王建伟[2] 刘玥[2] 侯小兵[5] 曹晓岚[6] 黎明全[7] 田军彪[8] 张玉莲[9] 戴中[10] 金香兰[4] 

机构地区：[1]国家食品药品监督管理总局药品审评中心,北京市100038 [2]北京中医药大学 [3]北京市第一中西医结合医院 [4]北京中医药大学东方医院 [5]中国中医科学院望京医院 [6]山东中医药大学附属医院 [7]长春中医药大学附属医院 [8]河北医科大学中医院 [9]天津中医药大学第二附属医院 [10]北京大学人民医院

出　　处：《中国全科医学》2015年第21期2498-2501,共4页Chinese General Practice

基　　金：2011年北京市科技计划项目(Z111107056811040);2014年度中医药行业科研专项(201407001);2010年度中医药行业科研专项(201007002)

摘　　要：目的临床验证血管性认知功能障碍自我辨识筛查方案(A、B卷)的应答率、鉴别度和同质性。方法于2008年2月—2014年9月采用临床流行病学横断面调查的研究方法选取山东中医药大学附属医院、北京中医药大学东方医院、天津中医药大学第二附属医院、长春中医药大学附属医院、河北医科大学中医院、北京大学人民医院、北京市丰台区丰台社区卫生服务中心、蒲黄榆社区卫生服务中心、方庄社区卫生服务中心、右安门社区卫生服务中心共计10个调查点门诊、住院患者及所辖社区居民4 008例。根据血管性认知功能障碍自我辨识筛查方案制定问卷,分为A、B卷进行题项筛选,采用题项分析、项目分析、同质性分析的方法。分析问卷的应答率、鉴别度和同质性。结果血管性认知功能障碍自我辨识筛查方案(A、B卷)各题项通过了题项筛选。其中,A、B卷各题项遗漏率均在5.00%以内;A、B卷高分组与低分组各题项得分比较,差异有统计学意义(P<0.01),临界比值均>3.00;A、B卷各题项与总分呈正相关(P<0.01),但A卷中A23、A24题项与总分的相关系数小于0.450;A卷总体Cronbach'sα系数为0.899,B卷总体Cronbach'sα系数为0.885,均大于0.700;删除题项后Cronbach'sα系数无升高;A卷中A23、A24题项因素负荷量均小于0.450。结论血管性认知功能障碍自我辨识筛查方案(A、B卷)各题项具有较好的应答率、鉴别度和同质性。Objective To clinically validate the self - screening program （ A volume and B volume） for vascular cognitive impairment. Methods From February 2008 to September 2014, we conducted clinical epidemiology cross - sectional survey on 4 008 subjects who were outpatients, inpatients or community residents enrolled from the Affiliated Hospital of Shandong University of Chinese Medicine, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, the Second Affiliated Hospital of Tianjin University of Chinese＂ Medicine, the Affiliated Hospital of Changchun University of Chinese Medicine, Chinese Medicine Hospital of Hebei Medical University, Renmin Hospital of Peking University, Fengtai Community Health Service Center, Puhuangyu Community Health Service Center, Fangzhuang Community Health Service Center, Youanmen Community Health Service Center. Questionnaires were designed according to the self - screening program for vascular cognitive impairment, and the questionnaire was divided into A volume and B volume. Question item analysis, item analysis and homogeneity analysis were undertaken. Results Question items were screened. The omission rates of A volume and B volume were both under 5.00%. For both A volume and B volume, the high score group and low score group were significantly different （P 〈 0. 01 ） in the average number of each question item, and the critical ratios were both higher than 3.00; the correlation between each question item and total score was significant （P 〈 0. 01 ）, while the correlation coefficient between the questionnaire items of A23 and A24 and the total score was lower than 0. 450. The overall Cronbach＇s c~ coefficient of volume A was 0. 899 and that of volume B was 0. 885, both higher than 0. 700. After the deletion of question items, there was no increase in the Cronbach＇s coefficient, the factor loadings of A23 and A24 were lower than 0. 450. Conclusion The question items of the self - screening program （A volume and B voiume） for vascular cognitive imp

关 键 词：认知功能障碍 诊断性自我评价 临床验证 

分 类 号：R741[医药卫生—神经病学与精神病学]