血必净注射液治疗中小量高血压性脑出血的疗效  

Effect of Xuebijing Injection on Small and Moderate Volumes of Hypertensive Cerebral Hemorrhage

作　　者：田自立[1] 

机构地区：[1]东南大学医学院附属蚌埠第一人民医院神经内科,安徽蚌埠233000

出　　处：《实用临床医学（江西）》2015年第7期12-14,17,共4页Practical Clinical Medicine

摘　　要：目的观察血必净注射液治疗高血压性脑出血的疗效。方法将经头颅CT检查确诊的60例急性高血压性脑出血(出血量<60mL)患者按随机数字表法分为2组,每组30例。对照组采用常规综合治疗(急性期绝对卧床休息、吸氧、保持呼吸道通畅,维持水、电解质平衡,如有颅内高压者给予脱水降颅内压,同时保持血压稳定,保护脑细胞及对症支持治疗等);治疗组在常规综合治疗基础上加用血必净20mg+生理盐水100mL静脉滴注,每天1次,28d为1个疗程。观察2组治疗后(第1、7、14、28天)血肿体积、血肿周围水肿体积变化及疗效(症状和体征)。结果 2组治疗后第7天血肿体积与第1天比较差异无统计学意义(P>0.05);治疗后第14、28天,2组血肿体积较第1、7天明显缩小,治疗组较对照组缩小更明显(均P<0.05)。2组治疗后第1、7、14天水肿体积变化比较差异均无统计学意义(均P>0.05);治疗后第28天治疗组水肿体积较对照组明显缩小(P<0.05)。治疗组总有效率为93.3%,对照组总有效率为73.3%,2组比较差异有统计学意义(P<0.05)。结论血必净注射液联合常规综合治疗中小量高血压性脑出血效果优于单纯常规综合治疗。Objective To observe the effect of Xuebijing injection on hypertensive cerebral hemorrhage.Methods Sixty patients with CT-confirmed acute hypertensive cerebral hemorrhage (<60 mL)were randomly divided into two groups,with 30 patients in each group.Patients in the control group received routine comprehensive treatment(absolute bed rest during the acute phase, oxygen inhalation,keeping the airway open,and maintaining water and electrolyte balance).Fur-thermore,patients with intracranial hypertension were treated by lowering intracranial pressure, maintaining blood pressure stabilization,protecting brain cells and performing symptomatic and supportive treatment.On the basis of routine comprehensive treatment,patients in treatment group were given intravenous infusion of Xuebijing 20 mg+normal saline 100 mL once per day for 28 days.Hematoma volume,edema volume,signs and symptoms were observed at 1,7,14 and 28 days after treatment in both groups.Results Compared with the volume at 1 day after treatment, the hematoma volume was not significantly improved at 7 days after treatment(P >0.05).Com-pared with the volume at 1 and 7 days after treatment,the hematoma volume was significantly re-duced at 14 and 28 days after treatment in both groups(all P <0.05).Moreover,the reduction in treatment group was more obvious than that in control group(P < 0.05).No significant differ-ences in edema volume were found between the two groups at 1,7 and 14 days after treatment (P >0.05).Compared with control group,edema volume was significantly reduced in treatment group at 28 days after treatment.In addition,the total effective rate in treatment group was signif-icantly higher than that in control group(93.3% vs 73.3%,P <0.05).Conclusion The combina-tion of Xuebijing injection and routine comprehensive joint treatment is superior to routine com-prehensive treatment alone for small and moderate volumes of hypertensive cerebral hemorrhage.

关 键 词：脑出血 高血压病 血必净 

分 类 号：R743.34[医药卫生—神经病学与精神病学]