α-烯醇化酶在肿瘤研究中的进展  

Alpha-Enolase in the Cancer Research

作　　者：陈小芸[1] 刘会玲[2] 张栋栋[1] 范维[1] 郭钰珍[1] 

机构地区：[1]兰州大学第二医院妇产科,兰州730030 [2]甘肃省人民医院妇产科,兰州730000

出　　处：《医学综述》2015年第13期2376-2379,共4页Medical Recapitulate

摘　　要：肿瘤在形成和发展过程中涉及多种与能量代谢有关的蛋白,这些蛋白可能提供促进肿瘤生长的正向环境,也可能参与对肿瘤抵抗和清除的防御反应。α-烯醇化酶(ENO1)作为一种多功能的蛋白,参与多种生理及病理过程,与肿瘤的发生、发展相关。研究发现,ENO1在头颈部肿瘤、呼吸系统肿瘤、消化系统肿瘤、妇科肿瘤及其他相关肿瘤中均有不同程度的表达。因此,ENO1可能成为预测某些肿瘤发生、发展、疗效及预后的辅助指标。The formation and progression of tumors involves many proteins related to energy metabo-lism,which provides positive effect or has defensive reaction in the development and progression of the tumors.As a multifunctional protein,α-enolase is involved in a variety of processes,including physiological and pathological processes,and is also related with the development of some diseases,particularly in the tumor′s pathogenesis.Current study found that α-enolase is expressed in the tumors of head and neck ,re-spiratory,digestive,gynecologic system.Thus,α-enolase may become the auxiliary indicator of the occur-rence,development and prognosis of certain tumors.

关 键 词：肿瘤 α-烯醇化酶 eno1基因 

分 类 号：R730.49[医药卫生—肿瘤]