颈动脉狭窄与认知功能障碍的相关性研究  

The Correlation Study of Carotid Stenosis and Cognitive Dysfunction

作　　者：王廉昌 程利萍[1] 王颖[2] 霍瑞民[1] 牛海玲[1] 

机构地区：[1]邯郸市第一医院神经内二科,河北邯郸056002 [2]邯郸市第一医院信息科,河北邯郸056002

出　　处：《医学综述》2015年第13期2443-2445,共3页Medical Recapitulate

摘　　要：目的探讨颈动脉狭窄与认知功能障碍的相关性。方法选择2011年5月至2014年2月邯郸市第一医院神经内科住院或门诊治疗的177例颈动脉狭窄患者为研究对象,根据颈动脉狭窄程度分为轻度狭窄58例,中度狭窄62例,重度狭窄57例,同期选择185例颈动脉未发生狭窄的门诊体检者作为颈动脉无狭窄组。比较各组受试者认知功能评分及完成时间,简易精神状态检查量表(MMSE)评分中各指标变化和合并症情况。结果中、重度狭窄组MMSE评分[(25.5±1.4)分、(23.8±1.3)分]显著低于轻度狭窄组[(28.7±1.7)分]和颈动脉无狭窄组[(29.2±1.6)分](P<0.05),而中、重度狭窄组完成时间[(8.1±1.1)min、(12.2±1.2)min]明显慢于轻度狭窄组[(5.6±1.3)min]和颈动脉无狭窄组[(4.8±1.5)min](P<0.05),重度狭窄组MMSE评分则明显低于中度狭窄组(P<0.05),而完成时间明显慢于中度狭窄组(P<0.05);颈动脉狭窄组患者MMSE评分中定向力、延迟回忆力、注意计算力、即刻回忆力、语言能力显著低于颈动脉无狭窄组(P<0.05),且随着狭窄程度加重上述指标均显著降低(P<0.05);颈动脉狭窄组患者糖尿病、短暂性脑缺血发作、高血压、脑白质病变及高尿酸血症发生率均显著高于颈动脉无狭窄组(P<0.05或P<0.01)。结论认知功能障碍与颈动脉狭窄存在一定的相关性,且随着狭窄程度的逐渐加深,认知功能损害程度也越严重。Objective To study the correlation of carotid artery stenosis and cognitive dysfunction . Methods A total of 177 patients with carotid artery stenosis admitted to the Inpatient/Outpatient Depart-ment of Handan City First Hospital from May 2011 to Feb.2014 were included in the study,which were divided into mild stenosis（58 cases）,moderate stenosis（62 cases）,severe stenosis（57 cases） according to the degree of carotid stenosis.At the same time,185 persons from the Outpatient Department for health exam-ination with no carotid artery stenosis were included as non-carotid artery stenosis group .The cognitive func-tion grade and finish time , mental state examination （ MMSE ） score indexes changes and complications of each group were compared.Results The MMSE scores of moderate stenosis and severe stenosis group were （25.5 ±1.4） and （23.8 ±1.3）,obviously lower than that of the mild stenosis and non-carotid artery steno-sis group（29.2 ±1.6）（P〈0.05）,while the completion time of moderate stenosis and severe stenosis group was （8.1 ±1.1） min and （12.2 ±1.2） min,significantly longer than that of mild stenosis and non-carotid artery stenosis group[（5.6 ±1.3） min and （4.8 ±1.5） min]（P〈0.05）.The directional force,delayed recall,attention to calculation,immediate memory,language ability index of MMSE score of carotid stenosis patients were significantly lower than those of non-carotid artery stenosis group（P〈0.05）,and with the nar-row degree aggravating,the above indicators were significantly decreased（P〈0.05）.The incidences of dia-betes,transient ischemic attack,hypertension,cerebral white matter lesions and high uric acid hematic dis-ease of carotid stenosis group were significantly higher than those of non-carotid artery stenosis group （ P 〈0.05 or P〈0.01）.Conclusion The cognitive dysfunction has certain relevance with carotid artery steno-sis,and with the narrow degree aggravates,the cognitive impairment becomes more serious.

关 键 词：颈动脉狭窄 认知功能 简易智能量表 

分 类 号：R741[医药卫生—神经病学与精神病学]