铂催化α-酮酸酯不对称氢化反应的研究进展  

Progress in Platinum-Catalyzed Asymmetric Hydrogenation of α-Keto Esters

作　　者：杨文[1] 潘雪静 杨定乔[1] 

机构地区：[1]教育部环境理论化学重点实验室华南师范大学化学与环境学院,广州510006

出　　处：《有机化学》2015年第6期1216-1228,共13页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21172081;21372090);广东省自然科学基金重点(No.S2013020013091);广州市科技计划(No.156300018)资助项目~~

摘　　要：铂催化α-酮酸酯不对称氢化反应是合成手性α-羟基酯的重要方法之一.综述了近年来铂催化α-酮酸酯不对称氢化多相反应的研究进展,重点讨论了修饰型铂催化剂、负载型铂催化剂、纳米簇和胶体铂催化剂等不同种类铂催化剂对不对称氢化反应的影响,并对可能的反应机理进行了讨论.Platinum-catalyzed enantioselective hydrogenation of α-keto esters is one of the most effective methods for the synthesis of chiral α-hydroxy esters. The recent progress in platinum-catalyzed heterogeneous asymmetric hydrogenation of α-keto esters is reviewed. It was paid great attention to the influences of modified platinum catalyst, supported platinum catalyst, nanoparticle platinum catalysts, and platinum colloids on the asymmetric hydrogenation. What＇s more, the possible mechanisms are also discussed in this review.

关 键 词：铂催化剂 α-酮酸酯 不对称氢化 金鸡纳生物碱 

分 类 号：O621.251[理学—有机化学]