肝癌间质及癌旁病变的临床病理意义  

Clinicopathological significance of interstitial and peritumoral stroma lesions in hepatocellular carcinoma

作　　者：于东升[1] 卓静[2] 

机构地区：[1]延安大学咸阳医院病理科,咸阳712000 [2]徐州市肿瘤医院病理科,徐州221005

出　　处：《中国肿瘤临床与康复》2015年第8期923-925,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨肝癌间质和癌旁病变对肝癌诊断的临床意义。方法选择2010年1月至2015年1月间延安大学咸阳医院病理科收治的肝癌组织患者80例,癌结节共180个。癌旁组织以及肝癌间质各取4块结节组织作为标本,常规包埋切片,显微镜观察结节情况。结果被完整内皮细胞围绕结节76个,其中<3 cm 52个,≥3 cm 24个。剩余104个结节均未被完整内皮细胞围绕,<3 cm 96个,≥3 cm仅8个。80例肝癌患者中,52例合并有肝硬化,68例合并有乙型肝炎病毒感染(HBV)且乙肝表面抗原(HBs Ag)阳性。结论病理进行连续切片并在显微镜下对肝癌间质及癌旁病变情况进行观察是目前临床预测肝癌患者预后的一个重要病理学指标。Objective To explore the clinicopathological significance of interstitial and peritumoral stroma lesions in hepatocellular carcinoma Methods From January 2010 to January 2015 in Xianyang Hospital Affiliated to Yan＇an University, 80 hepatocellular carcinoma patients were enrolled in the study, with 180 cancer nodes. The four parts in cancer nodes and adjacent tissues of liver cancer were selected. The specimens were observed under the microscope. Results For 76 nodes, the complete sinusoid endo- thelial cells were visible to surround the carcinoma cells, 52 nodes 〈3 cm and 24 nodes ≥3 cm. For 104 nodes, the incomplete sinusoid endothelial cells were surrounding the carcinoma cells, 96 nodes 〉13 cm and 8 nodes 〈 3 cm. There were 52 cases combined with hepatic sclerosis and 68 cases combined with hepatitis B virus （HBV） and positive hepatitis B surface antigen （HbsAg）. Conclusion The serial section and the observation of interstitial and adjacent diseases in liver cancer under the microscope is an important patho- logic index of predicting the prognosis of liver cancer.

关 键 词：肝肿瘤 间质病变 癌旁病变 病理 

分 类 号：R735.7[医药卫生—肿瘤]