不同程度近视眼LASIK术前及术后多焦ERG的变化  

Changes in the multifocal electroretinogram before and after LASIK in eyes with different degrees of myopia

作　　者：高瑞新[1] 赵俊华[1] 范玉香[1] 李朝霞[1] 

机构地区：[1]河北省沧州市中心医院眼一科,061001

出　　处：《中华眼视光学与视觉科学杂志》2015年第7期411-415,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

摘　　要：目的 对行准分子激光原位角膜磨镶术（LASIK）的不同程度近视患者术前及术后3个月均测定黄斑区不同部位的视网膜功能,然后评价其差异.方法 前瞻性对照研究.2012-2013年期间收集沧州市中心医院屈光门诊18～32岁的近视患者91例（169眼）,分为低度近视组30例（58眼）,中度近视组32例（57眼）和高度近视组29例（54眼）.所有患者均经过严格的术前检查,具备手术条件,术前及术后均应用德国Roland公司的多焦视网膜电流图（mERG）仪RETI-SCANK系统记录近视患者黄斑区mERG的一阶反应,分别测定各环N1、P1波的潜伏期和振幅密度.采用单因素方差分析和配对t检验比较3组术前及术后3个月各检查结果之间的差别.结果 各组术前及术后mERG的振幅密度在第1环最大,随离心度的增加均逐渐降低.潜伏期在第1环最小,随离心度增加均逐渐延长.不同程度的近视组术前及术后的mERG相比较发现;3组mERG各环的振幅密度及潜伏期在术前及术后比较,差异均无统计学意义.结论 LASIK对于近视眼眼底黄斑区视网膜功能没有影响.Objective To evaluate the changes in the function of the macular region in patients with different degrees of myopia at different sites on the retina before laser in situ keratomileusis （LASIK） and 3 months after LASIK.Methods Ninety-one patients （169 eyes）with myopia ranging in age from 18-32 years were enrolled from 2012 to 2013 for this prospective controlled study.Patients were divided into 3 groups：58 eyes,low myopia; 57 eyes,moderate myopia and 54 eyes,high myopia.All patients underwent strict examinations before the surgery was performed.All patients underwent multifocal electroretinogram （mERG） examinations using RETI-SCANK （Roland,Germany） to determine the function of the macular region before and after LASIK.The latencies and the amplitude densities of the P1 and N1 waves were measured at each ring.All exams were performed by the same surgeon.The distinctions among the 3 groups and before and after LASIK were then analyzed using ANOVA and paired t test.Results The study showed that the amplitude densities of the three groups before and after LASIK were the highest at ring one,which decreased rapidly but then increased at the most eccentric ring.The latencies were shortest at ring one,and delayed gradually at the more eccentric rings,and then increased at the farthest eccentricity.The tests showed that there were no statistically significant differences in amplitude densities or latencies between any group before or after LASIK.Conclusion LASIK surgery has no influence on the function of the macular region in myopic eyes.

关 键 词：视网膜电描记术 近视 角膜磨镶术 激光原位 黄斑 视网膜功能 

分 类 号：R779.63[医药卫生—眼科]