侧耳属真菌次级代谢产物化学及其生物学活性研究进展  

Research advances on the secondary metabolites produced by edible mushroom Pleurotus and their bioactivities

作　　者：马轲[1] 陶巧巧 汪锴[1,2] 韩俊杰[1] 宝丽[1] 刘宏伟[1] 

机构地区：[1]中国科学院微生物研究所真菌学国家重点实验室,北京100101 [2]中国科学院大学,北京100049

出　　处：《菌物学报》2015年第4期569-580,共12页Mycosystema

基　　金：国家重点基础研究发展规划(2014CB138304)

摘　　要：对侧耳属真菌次级代谢产物的化学及其生物学活性进展进行了综述。化学研究表明侧耳属真菌中蕴含有萜类、甾体类、酚酸衍生物、聚炔等多种结构类型的天然产物,这些化合物所具有的生物活性包括抗细菌、抗线虫、抗炎和抗肿瘤等。作用机制研究表明截短侧耳素类物质通过抑制肽酰转移酶活性而产生强抗菌作用;pleuroton B通过Bax/Bak通路诱导肿瘤细胞凋亡。The chemistry and biological activities of the secondary metabolites from Pleurotus spp. were reviewed products, including terpenes, steroids, phenolic derivatives and polyynes, with various biological activities, Natural such as antibacterium, anti-nematode activity, anti-inflammation, and anti-cancer, were reported during the past 60 years mechanism investigation indicated that pleuromutilin and its derivatives interact with the peptidyl transferase center to the growth of bacteria, and pleuroton B induced apoptosis via the classical Bax/Bak pathway Action inhibit

关 键 词：侧耳属 食用真菌 药用真菌 次级代谢产物 药用活性 

分 类 号：R284[医药卫生—中药学]