银杏叶黄酮注射液对ACI患者脑损伤因子影响研究  

Study on effect of brain injury factor in patients with acute cerebral infarction by Ginkgetin injection

作　　者：赵磊[1] 牟丽[1] 刘彦青[1] 李文涛[2] 

机构地区：[1]潍坊市益都中心医院神经内二科,山东潍坊262500 [2]潍坊医学院解剖教研室,山东潍坊261053

出　　处：《中国生化药物杂志》2015年第5期150-152,155,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨银杏叶黄酮注射液对急性脑梗死（acute cerebral infarction,ACI）患者脑损伤因子的影响及意义。方法选取2014年6月~2015年2月已确诊为急性脑梗死的患者180例,根据随机数字表法随机分为2组：对照组88例,行临床常规疗法治疗;实验组92例,在与对照组相同的临床常规治疗基础上加用银杏叶黄酮注射液,检测2组患者的临床疗效、神经功能缺损评分、及血清HIF-1α、TNF-α、Caspase-3水平,进而对比分析2种治疗方法的临床疗效。结果实验组患者经治疗后临床疗效更优于对照组,有效率显著优于对照组（P〈0.05）;神经功能缺损评分显著低于对照组（P〈0.05）;血清HIF-1α、Caspase-3、TNF-α水平低于对照组（P〈0.05）,均有统计学意义。结论银杏叶黄酮对急性脑梗死患者据有较好的临床疗效,且能有效改善患者神经功能缺损症状,对临床治疗脑梗死具有重要意义。Objective To explore effect of ginkgetin injection on brain damage factor in patients with acute cerebral infarction.Methods 180 cases of acute cerebral infarction patients were selected from June 2014 to February 2015, and divided into experiment group and control group.88 cases in control group were treated with clinical routine therapy, 92 cases in experimental group were treated on base of the control with ginkgetin injection, 2 weeks for a course.The clinical efficacy, MESS and serum HIF-1α, TNF-α, Caspase-3, were detected and compared.Results The clinical efficacy of the experiment group was better than that of control group（P〈0.05）,and the MESS of the experiment group was lower than the control group（P〈0.05）.Serum HIF-1α, Caspase-3, TNF-αlevels were lower than the control group（P〈0.05）.Conclusion Ginkgetin injection can effectively improve the patient’s neurological symptoms, it is of great significance to the clinical treatment of cerebral infarction.

关 键 词：银杏叶黄酮 急性脑梗死 神经功能缺损 HIF-1Α TNF-α CASPASE-3 

分 类 号：R74[医药卫生—神经病学与精神病学]