中医治疗精神分裂症药源性闭经临床观察  

Clinical observation of TCM treatment for schizophrenia with drug-induced amenorrhea

作　　者：柯素梅 周秀玉 林建忠 

机构地区：[1]漳州市福康医院,福建漳州363000

出　　处：《临床心身疾病杂志》2015年第4期144-145,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨中医治疗精神分裂症药源性闭经的临床疗效。方法将60例精神分裂症药源性闭经患者随机分为两组，每组30例，均维持原用抗精神病药物治疗，研究组联合中药血府逐瘀汤加减治疗，观察12周。治疗前后采用临床总体疗效评定量表评定临床疗效，副反应量表评定不良反应，并记录月经恢复状况。结果治疗后两组临床总体疗效评定量表评分呈逐渐下降趋势，同期两组间评分比较差异无显著性（P〉0．05）；两组均未出现明显不良反应，副反应量表评分比较差异无显著性（P〉0．05）。治疗12周末研究组月经恢复总有效率为93．3％，对照组闭经状况均无改善（未来月经），研究组总有效率显著高于对照组（P〈0．01）。结论中医药治疗精神分裂症药源性闭经疗效显著，安全性高。Objective To explore the efficacy of TCM treatment for schizophrenia with drug-induced amenorrhea, Methods Sixty schizophrenics with drug-induced amenorrhea were randomly assigned to two groups of 30 ones each, both groups maintained original antipsychotic treatment, research group was plus traditional Chinese drug of xuefu zhuyu tang for 12 weeks. Efficacies were assessed with the Clinical Global Impression （CGI） and adverse Scale （TESS） before and after treatment, menstruation reactions with the Treatment Emergent Symptom recovery states recorded. Results After treatment the CGI scores of both groups lowered gradually, there were no significant group differences in the corresponding period （P〉0.05）. Both groups had no obvious adverse reactions, the TESS score did no significant group difference （P〉0.05）. At the end of the 12th week total effective rate of menstruation recovery was 93.3% in research group, amenorrhea status didn＇t improve in control group, the total effective rate was significantly higher in research than in control group （P〈0.01）. Conclusion TCM treatment has an evident effect and higher safety for schizophrenia with drug-induced amenorrhea.

关 键 词：精神分裂症 药源性闭经 中医治疗 血府逐瘀汤 抗精神病药物 

分 类 号：R749.3[医药卫生—神经病学与精神病学]