单唾液酸神经节苷脂鞘内注射治疗恢复期脊髓损伤的临床研究  

Clinical study of intrathecal administration of GM1 ganglioside in the treatment of spinal cord injury during

作　　者：赖福生[1] 李惠俊[1] 焦冬生[1] 王燕燕[1] 钱时德 赵全[1] 卢少军[1] 

机构地区：[1]解放军第454医院神经科,南京210002

出　　处：《中国实用神经疾病杂志》2015年第15期10-12,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察单唾液酸神经节苷脂(GM1)鞘内注射治疗恢复期脊髓损伤的临床疗效。方法 46例脊髓损伤恢复期患者随机分为2组,对照组(n=23)给予综合性康复训练;治疗组(n=23)在对照组基础上给予GM1 40mg鞘内注射,每周1次,共3次。分别在治疗前和治疗第2个月末,采用ASIA评分标准对所有患者进行功能评定。结果治疗后2组患者ASIA评分均较治疗前显著增高(P<0.05),治疗组与对照组相比明显增高(P<0.05);3例鞘内注射后次日双下肢肌力明显增加;所有穿刺脑脊液压力均在正常范围内,脑脊液常规、生化和细胞学检测均未见异常;治疗中未出现严重不良反应。结论鞘内注射GM1治疗恢复期脊髓损伤效果良好,费用低廉,安全可行。Objective To investigate the curative effect of intrathecal administration of GM1 ganglioside in treating spinal cord injury（SCI）during convalescence.Methods A total of 46 patients with SCI during convalescence were randomly divided into two groups,the control group（n=23）was treated by comprehensive rehabilitation training;on the basis of comprehensive rehabilitation training,the treatment group（n=23）was given 40 mg GM1 through intrathecal injection for 3times,once a week.ASIA assessments were used to observe the patients before the treatment and at the end of second month of the treatment.Results ASIA scores were improved significantly after treatment in both two groups（P〈0.05）.The scores of treatment group were improved significantly than that of control group（P〈0.05）.The leg strengths of three patients in treatment group increased significantly in the next day after intrathecal administration of GM1.In every subarachnoid puncture,all the detection indexes of cerebrospinal fluid were normal.There was no serious adverse reaction in the treatment.Conclusion In the treatment of SCI during convalescence,intrathecal administration of GM1 is effective,cheap and practicable.

关 键 词：脊髓损伤恢复期 单唾液酸神经节苷脂 鞘内注射 

分 类 号：R744[医药卫生—神经病学与精神病学]