氟哌噻吨美利曲辛联合四联疗法治疗伴焦虑抑郁消化性溃疡患者的临床观察  

Clinical Observation on Effect of Flupentixol and Melitracen Combined with Quadruple Therapy on Peptic Ulcer Patients with Anxiety and Depression

作　　者：王震[1] 胡保奎[1] 丁百静[1] 

机构地区：[1]安徽省芜湖市第二人民医院消化内科,241000

出　　处：《胃肠病学》2015年第6期366-368,共3页Chinese Journal of Gastroenterology

摘　　要：背景:研究发现消化性溃疡患者易伴有焦虑抑郁情绪,并影响溃疡的治疗。目的:观察氟哌噻吨美利曲辛联合四联疗法治疗伴焦虑抑郁的消化性溃疡患者的临床疗效。方法:选取2012年5月-2013年5月芜湖市第二人民医院68例伴有焦虑抑郁的消化性溃疡患者,随机分为对照组和观察组。对照组采用四联疗法(雷贝拉唑20 mg+阿莫西林1.0 g+克拉霉素0.5 g+枸橼酸铋钾口服溶液10 mL,bid),观察组在此基础上联用氟哌噻吨美利曲辛,疗程均为2周。治疗结束后比较两组溃疡治疗有效率、幽门螺杆菌(Hp)根除率、焦虑抑郁治疗有效率、不良反应发生率和1年内溃疡复发率。结果:与对照组相比,观察组溃疡治疗有效率和Hp根除率明显升高(P<0.05),焦虑抑郁症状明显改善(P<0.05),不良反应发生率无明显差异,1年内溃疡复发率明显降低(P<0.05)。结论:对于伴有焦虑抑郁的消化性溃疡患者,氟哌噻吨美利曲辛联合四联疗法能显著提高治疗效果并能有效降低复发率。Background：Studies have shown that patients with peptic ulcer are susceptible to the accompanying of anxiety and depression,and affects the treatment of ulcer. Aims：To study the effect of flupentixol and melitracen combined with quadruple therapy on peptic ulcer patients with anxiety and depression. Methods：Sixty-eight peptic ulcer patients with anxiety and depression from May 2012 to May 2013 at Wuhu No. 2 People’s Hospital were enrolled,and were randomly divided into control group and observation group. Patients in control group were given quadruple therapy（ rabeprazole 20 mg ＋ amoxicillin 1. 0 g ＋ clarithromycin 0. 5 g ＋ colloidal bismuth subcitrate solution 10 mL,bid）,while patients in observation group were given flupentixol and melitracen in addition to quadruple therapy,the treatment course were both for 2 weeks. Therapeutic efficacy of ulcer,Helicobacter pylori（ Hp） eradication,therapeutic efficacy of anxiety and depression,incidence of adverse reaction and recurrence rate of ulcer within one year after treatment were compared between the two groups. Results：Compared with control group,the therapeutic efficacy of ulcer and Hp eradication in observation group were significantly increased（P 〈 0. 05）,therapeutic efficacy of anxiety and depression was significantly increased（P 〈 0. 05）,no significant difference in the incidence of adverse reaction was found between the two groups,and the recurrence rate of ulcer within one year was significantly decreased（ P 〈 0. 05）. Conclusions：Flupentixol and melitracen combined with quadruple therapy could significantly improve the therapeutic efficacy and effectively reduce the recurrence rate in peptic ulcer patients with anxiety and depression.

关 键 词：消化性溃疡 氟哌噻吨美利曲辛 幽门螺杆菌 焦虑 抑郁 治疗 

分 类 号：R573.1[医药卫生—消化系统]