老年2型糖尿病合并恶性肿瘤临床分析  

Analysis on cancer distribution in hospitalized type 2 diabetic patients with cancer

作　　者：张莹[1] 孟艳秋[1] 陈博[1] 

机构地区：[1]中国人民解放军成都军区总医院干部病房,四川成都610083

出　　处：《实用临床医药杂志》2015年第E01期44-46,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨老年2型糖尿病合并恶性肿瘤患者临床特征。方法采用回顾性队列研究的方式，连续收集2010年1月-2014年12月成都军区总医院收治的2771例老年2型糖尿病住院患者临床资料，分析恶性肿瘤的分布情况。结果恶性肿瘤检出率为6．8％（189／2771）。根据是否合并恶性肿瘤分组，恶性肿瘤组男性比例高于无恶性肿瘤组（58．2％vs．48．9％，P〈0．01）；恶性肿瘤组平均年龄（77．3±8．9）岁，高于无恶性肿瘤组的（72．8±11．6）岁，差异有统计学意义（P〈0．01）。恶性肿瘤分布：消化系统90例（47．6％）、呼吸系统39例（20．6％）、血液系统12例（6．3％）、女性生殖系统35例（18．5％）、男性泌尿生殖系统7例（3．7％）、其他类别肿瘤6例（3．2％）；前5位的疾病构成分别为：结直肠癌（16．4％）、肺癌（15．3％）、肝癌（14．3％）、乳腺癌（7．4％）、胰腺癌（5．3％）／子宫内膜癌（5．3％）。单因素分析显示：性别、年龄、吸烟、饮茶、糖尿病家族史为老年2型糖尿病患者并发恶性肿瘤的影响因素（P〈0．05）。结论2型糖尿病患者合并恶性肿瘤消化道肿瘤最为常见，性别、年龄、吸烟、饮茶、糖尿病家族史是并发恶性肿瘤的影响因素。Objective To Analysis the cancer distribution of hospitalized type 2 diabetic pa- tients, and to explore the risk factors of type 2 diabetes mellitus patients concomitant to cancer. Methods A retrospective cohort study was adopted to collect 2 771 cases of type 2 diabetic patients admitted to the department of cadres ward of General Hospital of Chengdu Military of PLA from January 2010 to December 2014. Clinical data of type 2 diabetes patients were collected for analysis of distribu- tion of the malignancies, Univariate analysis was used in screening risk factors of type 2 diabetes mellitus concomitant to cancer. Results A total of 189 （6.8%） as malignant group were detected with cancer. The proportion of men was significantly higher in malignant group than that in patients without cancer group （58.2% vs. 48.9% ,χ2 = 11. 855 ,P 〈0.01 ）, the average age of malignant group was higher than those without cancer [ （77.3 ±8.9）years vs. （72.8 ± 11.6） years,t =5. 222,P 〈0.011. Out of 189 pa- tients with cancer, 90 cases in digestive system （47.0%）, 39 cases with respiratory system （20.6%）, 12 cases with blood system （6.3%）, 35 cases with female reproductive system （ 18.5% ）, 7 cases with male genitourinary system （3.7%）, other types of tumors 6 cases （3. 6% ）. The top five cancer observed were： colorectal cancer （ 16.4% ）, lung cancer （ 15.3% ）, liver cancer （ 14. 3% ）, breast cancer （7.4%）, pancreatic cancer （5.3%）/endometrial cancer （5.3%）. Univariate analysis showed that gender, age, smoking, drinking, family history of diabetes were influencing factors for type 2 diabetes patients suffering malignant tumors. Conclusion The most common cancer in type 2 diabetic patients was gastrointestinal cancer. Gender, age, smoking, drinking, family history of diabetes are potentially influencing factors of type 2 diabetes patients suffering malignant tumors.

关 键 词：2型糖尿病 恶性肿瘤 影响因素 

分 类 号：R730.26[医药卫生—肿瘤]