雷奈酸锶对骨质疏松时种植体骨结合的影响  

Effect of Strontium Ranelate on Implant Osseointegration in Osteoporotic Rats

作　　者：王买全[1] 王永功[1] 彭利伟[1] 李亚东[1] 

机构地区：[1]郑州大学人民医院口腔科,河南郑州450003

出　　处：《口腔医学研究》2015年第7期673-675,共3页Journal of Oral Science Research

摘　　要：目的:研究雷奈酸锶治疗对骨质疏松时种植体骨结合的影响。方法:36只雌性SD大鼠随机分成骨质疏松组(A组,行双侧卵巢手术)、雷奈酸锶低剂量治疗组(B组,同A组手术)、雷奈酸锶高剂量治疗组(C组,同A组手术)(n=12),骨质疏松模型造模成功后,在SD大鼠右侧胫骨近中干骺端植入羟基磷灰石涂层种植体,同时B组给予雷奈酸锶450mg·kg-1·d-1口服,C组给予雷奈酸锶900mg·kg-1·d-1口服,种植术后12周,处死动物,标本制作不脱钙硬组织标本,行形态学、显微CT观察及骨计量学检测。结果:种植术后12周,B、C组种植体周骨密度、种植体骨结合率、新生骨量均显著高于A组(P<0.01),但C组与B组比较,各项指标差异不显著。结论:雷奈酸锶应用可拮抗骨质疏松的负面影响,促进种植体愈合,使种植体骨结合率增加。Objective：To investigate the effect of strontium ranelate on osseointergration in osteoporotic rats.Method：Thirty-six female rats were randomly divided into three groups：ovariectomization group（A=12）,strontium ranelate lower dose treatment group（B=12）and strontium ranelate high dose treatment group（C=12）.Animals all received bilateral ovariectomy.After the success of the osteoporosis model building,HA coated titanium implants were inserted into proximal metaphyses of tibiae,meanwhile,the animals of group B and C were received oral medication strontium ranelate（B：450mg·kg^-1·d^-1 C：900mg·kg^-1·d^-1）,Twelve weeks after surgery,animals were killed and undecalcified sections were prepared and examined histologically,micro-CT examnation and histomorphometrically.Results：12weeks after implantation surgery,BMD,IBCR and NBV in group B and C were significantly higher then those in group A（P〈0.01）.Conclusion：Strontium ranelate may resist the negative influence of osteoporosis and promote osseointagration of implant.

关 键 词：种植牙 雷奈酸锶 骨质疏松 骨结合 

分 类 号：R783.6[医药卫生—口腔医学]