幽门螺杆菌在胃食管反流病中的作用  

The role of Helicobacter pylori in gastroesophageal reflux disease

作　　者：刘燕[1] 于晓峰[1] 宓林[1] 

机构地区：[1]复旦大学附属华东医院消化科,上海200040

出　　处：《胃肠病学和肝病学杂志》2015年第7期807-809,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨幽门螺杆菌(H.pylori)感染与胃食管反流病(gastroesophageal reflux disease,GERD)的关系。方法收集并前瞻性分析2013年1月-2014年1月在复旦大学附属华东医院内镜室行胃镜检查的患者,纳入GERD患者984例及慢性浅表性胃炎患者2 136例,两组均行快速尿素酶试验进行H.pylori检测,对比两组H.pylori感染情况;将984例GERD患者分为NERD、RE-A、B组及RE-C、D组,对比三组H.pylori感染情况;随机选取60例H.pylori(+)GERD患者,均采用标准四联方案,其中54例成功根治H.pylori后的GERD患者继续随访3个月了解患者症状变化。结果 GERD组H.pylori感染的阳性率(35.98%)低于对照组(36.99%),但差异无统计学意义(P>0.05)。NERD组、RE-A、B组和RE-C、D组H.pylori感染率分别是36.19%、35.58%、35.96%,三组之间差异无统计学意义(P>0.05)。54例成功根除H.pylori的GERD患者随访3个月患者症状无明显改善。结论H.pylori感染与GERD之间无明显相关性,且H.pylori阳性GERD患者行H.pylori根治后症状无明显改善。Objective To investigate the relationship between H. pylori and gastroesophageal reflux disease（ GERD）. Methods From Jan. 2013 to Jan. 2014 in Huadong Hospital,984 patients with GERD and 2 136 patients with chronic superficial gastritis were included and analyzed prospectively,H. pylori infection was diagnosed by rapid urease test and13C-UBT,then H. pylori infection rate was compared between experimental group and control group; 984 patients with GERD were divided into NERD group,RE-A,B group and RE-C,D group,the H. pylori infection rate was compared. Sixty H. pylori（ ＋） GERD patients were selected randomly and received standard quadruple therapy randomly,54 cases successful eradication of H. pylori in GERD followed up for 3 months to know whether the symptoms had improved. Results The infection rate of H. pylori in GERD（ 35. 98%） was lower than that in control group（ 36. 99%）,there was no significant difference（ P〉0. 05）. The infection rates of H. pylori in NERD group,RE-A,B group,RE-C,D group were 36. 19%,35. 58%,35. 96%,respectively（ P〉0. 05）. Fifty-four GERD patients with successful eradication of H. pylori and follow-up of 3 months,their symptoms were not improved significantly. Conclusion There is no significant relationship between H. pylori infection and GERD,and for H. pylori positive GERD patients,symptoms are not improved significantly after eradication of H. pylori.

关 键 词：胃食管反流病 幽门螺杆菌 

分 类 号：R573[医药卫生—消化系统]