常规方式结合肠内营养治疗溃疡性结肠炎的临床效果观察  

Effects of enteral nutrition combined with routine methods on intestinal permeability in patients with ulcerative colitis

作　　者：邓绿[1] 

机构地区：[1]南方医科大学附属南海人民医院消化内科,广东佛山528200

出　　处：《胃肠病学和肝病学杂志》2015年第7期852-854,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨肠内营养(enteral nutrition,EN)对活动期溃疡性结肠炎患者肠道通透性的影响。方法采用随机数字表法将24例轻、中度活动期溃疡性结肠炎患者分为常规组(n=17)和常规+EN组(n=16),分别给予美沙拉秦+少渣饮食治疗和美沙拉秦+短肽型肠内营养剂治疗2周。采用高压液相色谱分析法分别检测治疗前后患者尿液中乳果糖及甘露醇的浓度,计算乳果糖/甘露醇排泄率的比值(L/M)。结果治疗前常规组和常规+EN组的L/M分别为0.032±0.021和0.035±0.016,两组比较差异无统计学意义(P=0.071)。治疗2周后,常规+EN组的L/M为0.012±0.011,明显低于治疗前(P=0.037),常规组的L/M为0.029±0.018,与治疗前比较差异无统计学意义(P=0.065)。结论 EN可以降低活动期溃疡性结肠炎患者的肠道通透性。Objective To investigate the effects of enteral nutrition（ EN） on intestinal permeability in patients with ulcerative colitis（ UC）. Methods 33 UC patients were randomly divided into two groups： routine treatment group（ n = 17） and routine treatment plus EN group（ n = 16）. Patients in routine treatment group were treated with mesalazine as well as low-residue diet,while patients in routine treatment plus EN group received mesalazine and short peptide EN for 2 weeks. The ratio of urinary excretion of lactulose to mannitol（ L / M） before and after treatment was detected by high-performance liquid chromatography. Results The L / M ratio was 0. 032 ± 0. 021 in routine treatment group and0. 035 ± 0. 016 in routine treatment plus EN group（ P = 0. 071）. After 2 weeks treatment,the L / M ratio of routine treatment plus EN group was significantly lower than the pretreatment level（ 0. 012 ± 0. 011 vs 0. 035 ± 0. 016,P =0. 037）,while the L / M ratio of routine treatment group had no significant difference（ 0. 032 ± 0. 021 vs 0. 029 ± 0. 018,P = 0. 065） between before and after treatment. Conclusion EN can effectively improve the intestinal permeability in UC patients.

关 键 词：溃疡性结肠炎 肠内营养 肠道通透性 

分 类 号：R574.62[医药卫生—消化系统]