视黄醇结合蛋白4的研究进展  

Advances in retinol-binding protein 4

作　　者：胡敏敏[1] 王晓青[1] 闫福媛 高璠[1] 琚坚[1] 

机构地区：[1]昆明医科大学第二附属医院特需病房科,云南昆明650101

出　　处：《胃肠病学和肝病学杂志》2015年第7期879-882,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：视黄醇结合蛋白4(retinol-binding protein 4,RBP4)属于视黄醇结合蛋白(RBP)家族中的分泌型RBP,主要在脂肪细胞和肝细胞分泌,在协助视黄醇发挥生理功能中起着不可替代的作用。研究人员于2005年发现RBP4是一种与胰岛素抵抗密切相关的新的脂肪因子,从不同的环节参与了胰岛素抵抗的发生、发展。近年来研究发现RBP4参与了非酒精性脂肪性肝病、2型糖尿病、心血管疾病等的调节。深入研究RBP4在相关疾病的作用机制及关键靶点有着重要的意义,可为疾病的预防、诊疗及预后判断提供新的方向。本文就近年来RBP4在相关疾病的研究进展作一概述。Retinol-binding protein 4（ RBP4） belongs retinol binding protein（ RBP） family of secreted RBP,secred in fat cells and liver cells primarily. RBP4 plays an irreplaceable role in helping retinol generate physiological functions.The researchers found that RBP4 is a new fat factor closely associated with insulin resistance in 2005,it involved in the development of insulin resistance from different sectors. Recent studies have found that RBP4 involved in non-alcoholic fatty liver disease,regulating type 2 diabetes,cardiovascular disease,etc. To study the mechanism and key targets of RBP4 related diseases has important significance for disease prevention,treatment and prognosis provide a new direction. In this review,we will summarize the research progress in RBP4 related diseases.

关 键 词：视黄醇结合蛋白4 非酒精性脂肪性肝病 代谢 心血管疾病 

分 类 号：R735.7[医药卫生—肿瘤]