广东清远地区妇女人乳头瘤病毒感染者合并沙眼衣原体感染情况的研究  

The research of women Human Papillomavirus and Chlamydozoa Trachomatis co-infection status in Qingyuan region Guangdong province

作　　者：黄振勇[1,2] 李介华[1,2] 刘艳枚[1,2] 吴爱娟[1,3] 胡庆兰[1,3] 岑欢[1,2] 周艳[1,4] 

机构地区：[1]暨南大学医学院第五附属医院 [2]清远市人民医院检验科,广东清远511518 [3]清远市人民医院妇科,广东清远511518 [4]清远市人民医院病理科,广东清远511518

出　　处：《国际检验医学杂志》2015年第14期1971-1972,共2页International Journal of Laboratory Medicine

基　　金：清远市科技计划项目(2009B011)

摘　　要：目的了解广东清远地区人乳头瘤病毒(HPV)感染者沙眼衣原体(CT)的感染状况。方法采用基因芯片分型技术对就诊者进行HPV 23种基因亚型的分型检测。利用实时荧光PCR对HPV阳性者进行CT检测。结果 23 983例标本中,HPV阳性为5 372例,有836例CT检测阳性。感染率前五位的HPV基因亚型合并CT感染例数由高到低依次为HPV-16(310/1 444,CT阳性/HPV阳性)、52(182/1 069)、56(101/643)、HPV-11(27/540)、66(83/446)。单一HPV亚型感染为的3 966例,其中438例合并CT感染;双重HPV亚型感染为1 061例,合并CT感染206例;三重感染为为223例,合并CT感染105例;四重以上感染为为122例,合并CT感染87例。随宫颈疾病及癌前病变程度的加重,高危型HPV合并CT感染率均显著上升,CINⅡ、CINⅢ和浸润癌均超过80%。结论本地区宫颈炎患者的HPV合并CT感染率较高,宫颈病变程度与HPV合并CT感染密切相关,长期持续高危型HPV合并CT感染可能导致宫颈癌。对HPV合并CT感染者进行长期的跟踪随访,对于降低宫颈癌的发病率等有着重要的意义。Objective To investigate the status of Chlamydia trachomatis（CT）infection with human papillomavirus（HPV）infected women in Qingyuan of Guangdong province.Methods The clinic visitors was examined by Nucleic Acid genotype chip technique and 23 subtypes of HPV were compared and analyzed.CT was detected by fluorescent quantitation polymerase chain reaction in HPV positive samples.Results Among the 23 983 samples,5 372 samples were HPV positive and 836 samples were CT positive.The top 5infection ratio of HPV subtypes and CT co-infected cases as follow：HPV-16（310/1 444,CT＋/HPV＋）,52（182/1 069）,56（101/643）,HPV-11（27/540）,66（83/446）.Of all HPV positive samples：the singe HPV subtypes infected samples was3966 and 438samples were CT co-infected;double HPV subtypes infected samples number was 1 061 and 206samples were CT coinfected;triple HPV subtypes infected samples number was 233 and 105samples were CT co-infected;Be more than or equal to quadruple HPV subtypes infected samples number was 122 and 87samples were CT co-infected.The ratio of high-risk HPV and CT co-infected was increased significantly with the deterioration of the degree of cervical disease and precancerous lesions,over 80%in CINⅡ,CINⅢ and invasive carcinoma.Conclusion the infection rate of HPV and CT co-infected is higher in cervicitis patient of Qingyuan region.There is closely relation between the degree of cervical lesion and HPV,CT co-infection and the long term of high risk HPV,CT co-infected status may induce cervical cancer.It′s important that have a long-term follow-up with HPV and CT co-infected person to reduce the incidence of cervical cancer.

关 键 词：人乳头瘤病毒 沙眼衣原体 合并感染 宫颈疾病 

分 类 号：R737.33[医药卫生—肿瘤]