基底细胞样型乳腺癌组织中TOPOIIα的表达及意义  

TOPOII-α Expression in Patients with Basal-like Breast Carcinoma Tissue and Its Clinical Significance

作　　者：周恬[1] 

机构地区：[1]贵州医科大学临床医学院,贵州贵阳550004

出　　处：《贵阳医学院学报》2015年第8期838-840,共3页Journal of Guiyang Medical College

摘　　要：目的:分析基底细胞样型乳腺癌(BLBC)癌灶组织中拓扑异构酶α(TOPOIIα)的表达及意义。方法:88例BLBC导管浸润癌患者作为观察组,同期非基底细胞样型导管浸润癌患者76例作为对照组,采用免疫组织化学方法检测两组患者癌灶组织中TOPOIIα的表达,分析其与BLBC病理特征的关系。结果:观察组TOPOIIα表达阳性率明显高于对照组,差异有统计学意义(P<0.05);BLBC癌灶组织中TOPOIIα表达与淋巴结转移、临床分期有关,差异有统计学意义(P<0.05);与年龄、民族、肿瘤大小、肿瘤组织学分级及临床分期无关,差异无统计学意义(P>0.05)。结论:癌灶组织中TOPOIIα阳性表达与BLBC发生、发展有关。Objective：To discuss the expression of topoisomerase-α（ TOPOⅡ-α）and its clinical sig-nificance in cancer tissue of basal-like breast carcinoma（ BLBC ）patients. Methods：Eighty- eight patients with BLBC were selected as observation group,76 patients with invasive ductal carcinoma of non-basal-like subtype served as control group. Immunohistochemical method was used to detect the expression of TOPOⅡ-α in cancer tissue of all patients,and its relationship with BLBC pathological characteristics and prognosis was analyzed. Results：Compared with control group,the positive rate of TOPOⅡ-α expression was significantly higher in observation group and the differences were statistically significant（ P ﹤0 . 05 ）. TOPOII-α expression in cancer tissue of BLBC was significantly associated with lymph node metastasis,clinical stage（P﹤0. 05）while TOPOⅡ-α expression in cancer tissue of BLBC has nothing to do with age,ethnicity and tumor size（P﹥0. 05）. Conclusions：TOPOⅡ-α ex-pression in cancer tissue of BLBC may be associated with BLBC occurrence,development,invasion and metastasis,which can be used as one effective judgment index of BLBC patient prognosis.

关 键 词：乳腺肿瘤 癌 基底细胞 拓扑异构酶 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]