微粉化对蒸附片粉体学性质的影响  

Influence of ultrafine grinding on micromeritic properties of Zhengfupian

作　　者：韩雪[1] 张定堃[1] 杨明[2] 郑全福[1] 郭治平 柯刚[2] 邹文铨[4] 傅超美[1] 

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004 [3]四川厚德医药科技有限公司,四川成都611731 [4]四川大学化学学院,四川成都610064

出　　处：《中草药》2015年第13期1901-1907,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81403115);四川省重大产业技术创新专项项目(2011ZY00299)

摘　　要：目的研究微粉化对蒸附片粉体学性质的影响,为其制剂及质量控制提供依据。方法采用超微粉碎机制备3种不同粉碎时间的蒸附片粉末,检测其粒径分布、比表面积与孔隙度、流动性、微观结构、红外光谱、吸湿性及溶出速率等性质,再对比进行综合分析。结果随着粉碎时间的增加,中粉、微粉I与微粉II的粒径逐渐减小,形态及结构趋于均匀化,但粒子易黏附聚集;同时比表面积与孔隙度增大;压缩度增大,休止角增大;红外光谱无明显变化;吸湿性无显著差异;溶出速率加快。结论综合蒸附片粉体学特征及溶出速率,蒸附片入丸散剂粉末超微粉碎时间宜控制在25 min左右,粒径d0.9宜在100.46μm左右。Objective To study the effect of ultrafine grinding on the micromeritic properties of Zhengfupian （steamed pieces of Aconiti Lateralis Radix Praeparata） and provide the basis for its preparation and quality control. Methods Three kinds of Zhengfupian powders were prepared by ultrafine grinding mill. Their micromeritic properties, including size distribution, surface area and porosity, flowability, scanning electronic microscope, infrared spectrum, moisture absorption and dissolution rate were detected. Then the effects were comprehensively analyzed. Results With the increasing of grinding time, the powder＇s particle size decreased, morphology and structure tended to be uniform, the specific surface area and porosity increased, the particles assembled easily, the compressibility and the angle of repose increased, the dissolution rate increased dramatically, and there were no significant changes in the infrared spectrum and moisture absorption. Conclusion As the micromeritic properties and dissolution rate of Zhengfupian are considered, Zhengfupian＇s ultrafine grinding time should be controlled at about 25 rain, particle size d0.9 should be around 100.46 μm.

关 键 词：蒸附片 超微粉碎 粉体学性质 溶出速率 孔隙度 微粉化 

分 类 号：R284.2[医药卫生—中药学]